IL-23 induces atopic dermatitis-like inflammation instead of psoriasis-like inflammation in CCR2-deficient mice

Psoriasis is an immune-mediated chronic inflammatory skin disease, characterized by epidermal hyperplasia and infiltration of leukocytes into the dermis and epidermis. IL-23 is expressed in psoriatic skin, and IL-23 injected into the skin of mice produces IL-22-dependent dermal inflammation and acan...

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Veröffentlicht in:	PloS one 2013-03, Vol.8 (3), p.e58196
Hauptverfasser:	Bromley, Shannon K, Larson, Ryan P, Ziegler, Steven F, Luster, Andrew D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Animals Atopic dermatitis Biology CC chemokine receptors CCR2 protein CD4-Positive T-Lymphocytes - immunology Chemokines Cytokines Cytokines - immunology Dendritic cells Dermatitis Dermatitis, Atopic - chemically induced Dermis Disease Disease Models, Animal Ear Eczema Eosinophils Eosinophils - immunology Epidermis Gene Expression Regulation Helper cells Hospitals Humans Hyperplasia Immune response Immunology Infections Infiltration Inflammation Inflammation - chemically induced Inflammatory diseases Interleukin 22 Interleukin 23 Interleukin 4 Interleukin-23 - adverse effects Interleukin-4 - immunology Lesions Leukocytes Leukocytes (eosinophilic) Ligands Lymphocytes Lymphocytes T Mast Cells - immunology Medicine Mice Mice, Inbred C57BL Mice, Transgenic Monocyte chemoattractant protein 1 Neutrophils - immunology Pathogenesis Psoriasis Psoriasis - chemically induced Receptors, CCR2 - genetics Rheumatology Rodents Signal Transduction Skin Skin diseases Thickening Thymic stromal lymphopoietin
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