Single nucleotide polymorphisms in MCP-1 and its receptor are associated with the risk of age related macular degeneration

Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly population. We have shown previously that mice deficient in monocyte chemoattractant protein-1 (MCP1/CCL2) or its receptor (CCR2) develop the features of AMD in senescent mice, however, the human genetic evidence...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e49905-e49905
Hauptverfasser:	Anand, Akshay, Sharma, Neel Kamal, Gupta, Amod, Prabhakar, Sudesh, Sharma, Suresh Kumar, Singh, Ramandeep, Gupta, Pawan Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Age related diseases Aged Atherosclerosis Biology Blindness Blood proteins CC chemokine receptors CCR2 protein Chemokine CCL2 - genetics Chemokines Chromosomes Cytokines Cytometry Diabetic retinopathy Disease Enzyme-linked immunosorbent assay Enzymes Female Flow Cytometry Gene frequency Genetic aspects Genetic Association Studies Geriatrics Health education Heart attacks Humans Leukocytes (mononuclear) Macular degeneration Macular Degeneration - genetics Macular Degeneration - pathology Male Medical research Medicine Mice Middle Aged Monocyte chemoattractant protein Monocyte chemoattractant protein 1 Neurology Older people Pathogenesis Patients Peripheral blood mononuclear cells Photoreceptors Physiological aspects Polymorphism Polymorphism, Single Nucleotide Population Proteins Receptors, CCR2 - genetics Retina Risk Factors Single nucleotide polymorphisms Single-nucleotide polymorphism Studies
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