A novel mechanism of PPAR gamma induction via EGFR signalling constitutes rational for combination therapy in bladder cancer

Two signalling molecules that are attractive for targeted therapy are the epidermal growth factor receptor (EGFR) and the peroxisome proliferator-activated receptor gamma (PPARγ). We investigated possible crosstalk between these 2 pathways, particularly in light of the recent evidence implicating PP...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55997
Hauptverfasser:	Mansure, Jose Joao, Nassim, Roland, Chevalier, Simone, Szymanski, Konrad, Rocha, Joice, Aldousari, Saad, Kassouf, Wassim
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antineoplastic agents Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Biology Biotechnology Bladder Bladder cancer Cancer Cancer therapies Cancer treatment CCAAT-Enhancer-Binding Protein-beta - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cell cycle Cell growth Cell Line, Tumor Cell proliferation Combination therapy Comparative analysis Crosstalk Cyclin-dependent kinases Diabetes Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Epidermal growth factor Epidermal growth factor receptors Epidermal growth factors Female Gefitinib Gene Expression Gene Expression Regulation, Neoplastic - drug effects Health aspects Humans Immunoglobulins Inhibition Kinases Medicine Metastasis Mice Mutation Oncology Peroxisome proliferator-activated receptors PPAR gamma - agonists PPAR gamma - genetics PPAR gamma - metabolism Protein binding Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - pharmacology PTEN Phosphohydrolase - genetics PTEN Phosphohydrolase - metabolism Quinazolines - administration & dosage Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Rodents Signal transduction Signal Transduction - drug effects Signaling Therapy Transcription activation Tumor Burden - drug effects Tumor cell lines Tumors Urinary bladder Urinary Bladder Neoplasms - drug therapy Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology Urology Xenograft Model Antitumor Assays
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