Silencing of APE1 enhances sensitivity of human hepatocellular carcinoma cells to radiotherapy in vitro and in a xenograft model

Resistance to radiotherapy is a key limitation for the treatment of human hepatocellular carcinoma (HCC). To overcome this problem, we investigated the correlation between radioresistance and the human apurinic/apyrimidinic endonuclease (APE1), a bifunctional protein, which plays an important role i...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55313-e55313
Hauptverfasser:	Cun, Yanping, Dai, Nan, Xiong, Chengjie, Li, Mengxia, Sui, Jiangdong, Qian, Chengyuan, Li, Zheng, Wang, Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - genetics Apoptosis - radiation effects Biology Biotechnology Bone cancer Cancer therapies Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - radiotherapy Cell cycle Cell growth Cell Line, Tumor Colorectal cancer Deoxyribonucleic acid DNA DNA binding proteins DNA damage DNA repair DNA-(Apurinic or Apyrimidinic Site) Lyase - genetics DNA-(Apurinic or Apyrimidinic Site) Lyase - metabolism Dose-Response Relationship, Radiation Down-Regulation Endonuclease Enzymes Gene expression Gene regulation Gene Silencing - physiology Growth inhibition Hepatocellular carcinoma Humans Inhibition Ionizing radiation Irradiation Liver cancer Liver Neoplasms - genetics Liver Neoplasms - radiotherapy Medicine Mice Multiple myeloma Neoplasm Transplantation p53 Protein Proteins Radiation dosage Radiation therapy Radiation Tolerance Radioresistance Radiosensitivity Radiotherapy RNA, Small Interfering Rodents Sensitivity Sensitivity enhancement siRNA Studies Surgery Transcription (Genetics) Transcription factors Transplantation, Heterologous Tumor proteins Tumors Xenografts
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