MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

Mitochondrial calcium uptake is present in nearly all vertebrate tissues and is believed to be critical in shaping calcium signaling, regulating ATP synthesis and controlling cell death. Calcium uptake occurs through a channel called the uniporter that resides in the inner mitochondrial membrane. Re...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55785-e55785
Hauptverfasser:	Plovanich, Molly, Bogorad, Roman L, Sancak, Yasemin, Kamer, Kimberli J, Strittmatter, Laura, Li, Andrew A, Girgis, Hany S, Kuchimanchi, Satya, De Groot, Jack, Speciner, Lauren, Taneja, Nathan, Oshea, Jonathan, Koteliansky, Victor, Mootha, Vamsi K
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Bioinformatics Biology Calcium Calcium (mitochondrial) Calcium - metabolism Calcium Channels - chemistry Calcium Channels - genetics Calcium Channels - metabolism Calcium influx Calcium Signaling Calcium signalling Calcium-Binding Proteins - genetics Calcium-Binding Proteins - metabolism Cation Transport Proteins - genetics Cation Transport Proteins - metabolism Cell death Cell Respiration - genetics Departments Electron transport Gene duplication Gene expression Genes Genomes Genomics HEK293 Cells HeLa Cells Hospitals Humans Liver Liver - metabolism Medical research Medical schools Medicine Membrane potential Membrane Potential, Mitochondrial - genetics Metabolism Mice Mitochondria Mitochondria - genetics Mitochondria - metabolism Mitochondrial Membrane Transport Proteins - genetics Mitochondrial Membrane Transport Proteins - metabolism Molecular biology Multigene Family Multiprotein Complexes - metabolism Pharmaceuticals Pore formation Protein Binding Protein Stability Protein Transport Proteins RNA Interference RNA-mediated interference Science Sequence Alignment Silence Tissues
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