Relationship between knockdown resistance, metabolic detoxification and organismal resistance to pyrethroids in Anopheles sinensis

Anopheles sinensis is the most important vector of malaria in Southeast Asia, including China. Currently, the most effective measure to prevent malaria transmission relies on vector control through the use of insecticides, primarily pyrethroids. Extensive use of insecticides poses strong selection p...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55475
Hauptverfasser:	Zhong, Daibin, Chang, Xuelian, Zhou, Guofa, He, Zhengbo, Fu, Fengyang, Yan, Zhentian, Zhu, Guoding, Xu, Tielong, Bonizzoni, Mariangela, Wang, Mei-Hui, Cui, Liwang, Zheng, Bin, Chen, Bin, Yan, Guiyun
Format:	Artikel
Sprache:	eng
Schlagworte:	Agriculture Agrochemicals Analysis Animals Anopheles Anopheles - drug effects Anopheles - genetics Anopheles - metabolism Anopheles gambiae Anopheles sinensis Aquatic insects Binding sites Biology Catabolism China Culicidae Culicidae - drug effects Deltamethrin Detoxification Disease control Disease transmission Enzymes Gene Knockdown Techniques Genotype Glutathione Glutathione Transferase - genetics Glutathione Transferase - metabolism Health sciences Inactivation, Metabolic - genetics Insect Vectors - genetics Insecticide resistance Insecticide Resistance - drug effects Insecticide Resistance - genetics Insecticides Insecticides - pharmacology Life sciences Malaria Metabolism Mixed Function Oxygenases - genetics Mixed Function Oxygenases - metabolism Molecular biology Monooxygenase Mosquito Control - methods Mosquitoes Mutation Mutation - drug effects Mutation - genetics Nitriles - pharmacology Oryza ParA gene Parasitic diseases Pathogens Pest control Populations Public health Pyrethrins - pharmacology Pyrethroids Regression analysis Rice Sodium Sodium channels Transferases Vector-borne diseases
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