Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of MGAM and ADAM9

Despite the advances in diagnosis and treatment of oral squamous cell carcinoma (OSCC), mortality and morbidity rates have not improved over the past decade. A major drawback in diagnosis and treatment of OSCC is the lack of knowledge relating to how genetic instability in oral cancer genomes affect...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e54705
Hauptverfasser:	Vincent-Chong, Vui King, Anwar, Arif, Karen-Ng, Lee Peng, Cheong, Sok Ching, Yang, Yi-Hsin, Pradeep, Padmaja Jayaprasad, Rahman, Zainal Ariff Abdul, Ismail, Siti Mazlipah, Zaini, Zuraiza Mohamad, Prepageran, Narayanan, Kallarakkal, Thomas George, Ramanathan, Anand, Mohayadi, Nur Aaina Binti Mohd, Rosli, Nurul Shielawati Binti Mohamed, Mustafa, Wan Mahadzir Wan, Abraham, Mannil Thomas, Tay, Keng Kiong, Zain, Rosnah Binti
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - biosynthesis ADAM Proteins - genetics alpha-Glucosidases - biosynthesis alpha-Glucosidases - genetics Amplification Amylases Analysis Annotations Bioindicators Biology Biomarkers Cancer Cancer genetics Carcinogenesis Carcinogens Carcinoma, Squamous Cell - enzymology Carcinoma, Squamous Cell - genetics Care and treatment Cell adhesion & migration Chromosome 11 Chromosome 8 Chromosome Aberrations Cloning Copy number Cytogenetics Dentistry Diagnosis DNA Copy Number Variations DNA polymerases Gene amplification Gene expression Genes Genetic aspects Genome-Wide Association Study - methods Genomes Genomic instability Genomics Glucoamylase Glucosidase Health aspects Humans Hybridization Maxillofacial surgery Medical diagnosis Medical prognosis Medical research Medicine Membrane Proteins - biosynthesis Membrane Proteins - genetics Metalloproteinase Morbidity Mortality Mouth Mucosa - enzymology Mouth Mucosa - pathology Mouth Neoplasms - enzymology Mouth Neoplasms - genetics Oral cancer Oral carcinoma Oral hygiene Oral squamous cell carcinoma Overexpression Pathology Polymerase chain reaction RNA RNA, Messenger - genetics RNA-directed DNA polymerase SHPS-1 protein Squamous cell carcinoma Stability Studies Surgery Tumors α-Glucosidase
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