Zfp148 deficiency causes lung maturation defects and lethality in newborn mice that are rescued by deletion of p53 or antioxidant treatment

The transcription factor Zfp148 (Zbp-89, BFCOL, BERF1, htβ) interacts physically with the tumor suppressor p53 and is implicated in cell cycle control, but the physiological role of Zfp148 remains unknown. Here we show that Zfp148 deficiency leads to respiratory distress and lethality in newborn mic...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55720
Hauptverfasser:	Sayin, Volkan I, Nilton, Anna, Ibrahim, Mohamed X, Ågren, Pia, Larsson, Erik, Petit, Marleen M, Hultén, Lillemor Mattsson, Ståhlman, Marcus, Johansson, Bengt R, Bergo, Martin O, Lindahl, Per
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Antioxidants Antioxidants (Nutrients) Antioxidants - pharmacology Apoptosis Biochemistry Biology Blotting Blotting, Southern Blotting, Western Cancer Cell and Molecular Biology Cell Cycle Cell differentiation Cell Proliferation Cell- och molekylärbiologi Cells Cells, Cultured Clinical Medicine Clonal deletion Cultured cytology Defects deficiency Deoxyribonucleic acid Developmental stages DNA DNA-Binding Proteins DNA-Binding Proteins - physiology drug effects Embryo Embryo, Mammalian - cytology Embryo, Mammalian - drug effects Embryo, Mammalian - metabolism embryology Female Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Gene Deletion Genes Genes, Lethal genetics Hypoxia Immunoenzyme Techniques Inbred C57BL Kinases Klinisk medicin Knockout Laboratories Lethal Lethality Lung Lung - drug effects Lung - embryology Lung - metabolism Lungs Mammalian Maturation Medicine Messenger metabolism Mice Mice, Inbred C57BL Mice, Knockout Newborn Newborn infants Oxidative Stress Oxidative Stress - drug effects p53 Protein pathology pharmacology Physiology prevention & control Proteins Real-Time Polymerase Chain Reaction Respiratory Tract Diseases Respiratory Tract Diseases - genetics Respiratory Tract Diseases - pathology Respiratory Tract Diseases - prevention & control Reverse Transcriptase Polymerase Chain Reaction RNA RNA, Messenger - genetics Rodents Saccule Senescence Southern Surfactants Transcription Factors Transcription Factors - physiology Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 Tumor Suppressor Protein p53 - deficiency Tumor Suppressor Protein p53 - genetics Western
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