The two-component adjuvant IC31® boosts type i interferon production of human monocyte-derived dendritic cells via ligation of endosomal TLRs

The aim of this study was to characterize and identify the mode of action of IC31®, a two-component vaccine adjuvant. We found that IC31® was accumulated in human peripheral blood monocytes, MHC class II positive cells and monocyte-derived DCs (moDCs) but not in plasmacytoid DCs (pDCs). In the prese...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e55264-e55264
Hauptverfasser:	Szabo, Attila, Gogolak, Peter, Pazmandi, Kitti, Kis-Toth, Katalin, Riedl, Karin, Wizel, Benjamin, Lingnau, Karen, Bacsi, Attila, Rethi, Bence, Rajnavolgyi, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - pharmacology Antigens Bioaccumulation Biological response modifiers Biology Blood & organ donations Blood transfusions Cell Differentiation - drug effects Cell Differentiation - immunology Cells, Cultured Chemokines Chemokines - immunology Cytokines Dendritic cells Dendritic Cells - drug effects Dendritic Cells - immunology Drug Combinations Endosomes - drug effects Endosomes - immunology Gene expression Humans I-kappa B Proteins - biosynthesis I-kappa B Proteins - immunology Immune response Immune system Immunology Inflammation Interferon Interferon regulatory factor 3 Interferon Regulatory Factor-3 - immunology Interferon Type I - biosynthesis Interferon Type I - immunology Interferon-beta - immunology Interleukin 6 Interleukin-6 - immunology Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Ligands Ligation Major histocompatibility complex Medicine Mode of action Monocytes NF-kappa B - immunology NF-KappaB Inhibitor alpha NF-κB protein Oligodeoxyribonucleotides - immunology Oligodeoxyribonucleotides - pharmacology Oligopeptides - immunology Oligopeptides - pharmacology Pattern recognition Peptides Peripheral blood Phosphorylation Production management Proteins Science Signaling T cell receptors TLR3 protein TLR7 protein TLR9 protein Toll-like receptors Toll-Like Receptors - immunology Tumor Necrosis Factor-alpha - immunology Tumor necrosis factor-α Vaccination Vaccines
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