Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice

Tissue plasminogen activator (tPA) is the only FDA-approved treatment for reperfusing ischemic strokes. But widespread use of tPA is still limited by fears of inadvertently administering tPA in patients with intracerebral hemorrhage (ICH). Surprisingly, however, the assumption that tPA will worsen I...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e54203-e54203
Hauptverfasser:	Foerch, Christian, Rosidi, Nathanael L, Schlunk, Frieder, Lauer, Arne, Cianchetti, Flor A, Mandeville, Emiri, Arai, Ken, Yigitkanli, Kazim, Fan, Xiang, Wang, Xiaoying, van Leyen, Klaus, Steinmetz, Helmuth, Schaffer, Chris B, Lo, Eng H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animal tissues Animals Anticoagulants Biological effects Biology Biomedical engineering Brain research Case-Control Studies Cerebral Hemorrhage - pathology Collagen Collagenase Drug approval Drug therapy Edema Enzymes FDA approval Hematoma Hemorrhage Heparin Intracerebral hemorrhage Intravenous administration Ischemia Laboratories Male Matrix metalloproteinases Medical schools Medicine Mice Neurological diseases Neurology Neurosurgery Rodents Stroke t-Plasminogen activator Therapy Thromboembolism Thrombolytic drugs Tissue plasminogen activator Tissue Plasminogen Activator - therapeutic use
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