Vitamin D3 at 50x AI Attenuates the Decline in Paw Grip Endurance, but Not Disease Outcomes, in the G93A Mouse Model of ALS, and Is Toxic in Females

Background We previously demonstrated that dietary vitamin D3 at 10x the adequate intake (AI) attenuates the decline in functional capacity in the G93A mouse model of ALS. We hypothesized that higher doses would elicit more robust changes in functional and disease outcomes. Objective To determine th...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e30243
Hauptverfasser:	Gianforcaro, Alexandro, Solomon, Jesse A., Hamadeh, Mazen J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Amyotrophic lateral sclerosis Attenuation Biology Body weight Brain research Diet Dietary supplements Durability Endurance Enzymes Females Food intake Gene expression Growth factors Kinesiology Laboratories Life span Medical research Medicine Metabolism Metabolites Mice Motor task performance Nervous system Nutrition research Oxidative stress Paralysis Pathology Rodents Spinal cord Toxicity Transgenic Veterinary Science Vitamin D Vitamin D3
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