Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity

Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-κΒ) transcription factors are upregulated by IR and have been implicated in radioresistance. We evaluated the ability of curcumin, a putative NF-κΒ inhibitor, and cells expressing ge...

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Veröffentlicht in:	PloS one 2013-02, Vol.8 (2), p.e51309-e51309
Hauptverfasser:	Orr, W Shannon, Denbo, Jason W, Saab, Karim R, Ng, Catherine Y, Wu, Jianrong, Li, Kui, Garner, Jo Meagan, Morton, Christopher L, Du, Ziyun, Pfeffer, Lawrence M, Davidoff, Andrew M
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Alveoli Angiogenesis Animals Anticancer properties Antitumor activity Apoptosis Biology Blotting, Western Breast cancer Cancer therapies Cell growth Cell Line, Tumor Cell Proliferation Children & youth Clinical trials Colorectal cancer Curcumin Curcumin - pharmacology Drug dosages Endothelial cells Gene expression Humans I.R. radiation Immunohistochemistry In vivo methods and tests Inhibition Ionizing radiation Kinases Medical prognosis Medical research Medicine Metastasis Mice Neuroblastoma NF-kappa B - metabolism NF-κB protein Pathology Pharmacology Pretreatment Proteins Radiation Radiation effects Radiation therapy Radiation Tolerance Radiation, Ionizing Radioresistance Radiosensitivity Rhabdomyosarcoma Rhabdomyosarcoma, Alveolar - blood supply Rhabdomyosarcoma, Alveolar - metabolism Rhabdomyosarcoma, Alveolar - pathology Science Surgery Transcription factors Xenograft Model Antitumor Assays Xenografts
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