A quantitative proteomic profile of the Nrf2-mediated antioxidant response of macrophages to oxidized LDL determined by multiplexed selected reaction monitoring

The loading of macrophages with oxidized low density lipoprotein (LDL) is a key part of the initiation and progression of atherosclerosis. Oxidized LDL contains a wide ranging set of toxic species, yet the molecular events that allow macrophages to withstand loading with these toxic species are not...

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Veröffentlicht in:	PloS one 2012-11, Vol.7 (11), p.e50016
Hauptverfasser:	Kinter, Caroline S, Lundie, Jillian M, Patel, Halee, Rindler, Paul M, Szweda, Luke I, Kinter, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Antioxidants Antioxidants (Nutrients) Arteriosclerosis Assaying Atherosclerosis Atherosclerosis - metabolism Atherosclerosis - physiopathology Biology Blotting, Western Cell Line Cellular stress response Chemistry Chromatography, Liquid Cytokines Cytotoxicity Experiments Foams Free radicals Gene expression Gene Expression Regulation - genetics Gene Expression Regulation - physiology Hydroquinones Hypotheses Lipids Lipoproteins, LDL - metabolism Low density lipoprotein Low density lipoproteins Macrophages Macrophages - metabolism Mass spectrometry Medical research Medicine Mice Monitoring Multiplexing NF-E2-Related Factor 2 - metabolism Oxidation-Reduction Protein expression Proteins Proteomics Proteomics - methods RNA, Small Interfering - genetics Scientific imaging siRNA Statistical analysis Statistical significance Stress Stress response Stresses t-Butylhydroquinone Tandem Mass Spectrometry
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