Cryptococcus gattii induces a cytokine pattern that is distinct from other cryptococcal species

Understanding more about the host's immune response to different Cryptococcus spp. will provide additional insight into the pathogenesis of cryptocococcis. We hypothesized that the ability of C. gattii to cause disease in immunocompetent humans depends on a distinct innate cytokine response of...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e55579-e55579
Hauptverfasser:	Schoffelen, Teske, Illnait-Zaragozi, Maria-Teresa, Joosten, Leo A B, Netea, Mihai G, Boekhout, Teun, Meis, Jacques F, Sprong, Tom
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Candida albicans Cryptococcus Cryptococcus - classification Cryptococcus - immunology Cryptococcus gattii - immunology Cryptococcus neoformans Cytokines Cytokines - biosynthesis Cytokines - immunology Experiments Fungal infections Helper cells Hospitals Humans Immune response Immune system Infectious diseases Inflammation Inflammatory response Interleukin 17 Interleukin 22 Interleukin 6 Leukocytes (mononuclear) Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Lymphocytes T Medicine Microorganisms Pathogenesis Pathogens Pattern recognition Peripheral blood mononuclear cells Receptors Receptors, Pattern Recognition - metabolism Species Specificity T cell receptors TLR2 protein TLR4 protein TLR9 protein Toll-like receptors Toll-Like Receptors - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α
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