Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity
We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfe...
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| description | We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfect.
In 111 patients with RA, we examined longitudinal and cross-sectional correlations of blood PTX3, MCP-1, CRP, and ESR levels with measures of clinical arthritic activity, namely, swollen joint count (SJC), tender joint count (TJC), visual analog scale for general health (GH), DAS28, and adapted DAS28-MCP-1.
Blood MCP-1, but not PTX3, was significantly correlated with SJC, TJC, DAS28, and DAS28-CRP. DAS28-MCP-1 was strongly correlated with DAS28 (r = 0.984, P |
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In 111 patients with RA, we examined longitudinal and cross-sectional correlations of blood PTX3, MCP-1, CRP, and ESR levels with measures of clinical arthritic activity, namely, swollen joint count (SJC), tender joint count (TJC), visual analog scale for general health (GH), DAS28, and adapted DAS28-MCP-1.
Blood MCP-1, but not PTX3, was significantly correlated with SJC, TJC, DAS28, and DAS28-CRP. DAS28-MCP-1 was strongly correlated with DAS28 (r = 0.984, P<0.001) and DAS28-CRP (r = 0.971, P<0.001), and modestly correlated with CRP (r = 0.350, P<0.001), and ESR (r = 0.386, P<0.001). Similarly, the duration of arthritic symptoms, but not sex, was significantly correlated with variables of arthritic activity. In particular, DAS28-MCP-1 significantly correlated with DAS28 during a 6-month period (r = 0.944, P<0.001; r = 0.951, P<0.001; r = 0.862, P<0.001; and r = 0.865, P<0.001 for month 0, 1, 3, and 6, respectively).
Blood MCP-1 and adapted DAS28-MCP-1, but not blood PTX3, may be useful in monitoring RA activity.]]></description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0055346</identifier><identifier>PMID: 23383162</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Arthritis ; Arthritis, Rheumatoid - blood ; Arthritis, Rheumatoid - diagnosis ; Arthritis, Rheumatoid - pathology ; Biology ; Biomarkers - blood ; Blood ; Blood Sedimentation ; Blood tests ; C-reactive protein ; C-Reactive Protein - analysis ; C-Reactive Protein - metabolism ; Chemokine CCL2 - blood ; Cross-Sectional Studies ; Disease ; Enzyme-Linked Immunosorbent Assay ; Erythrocyte sedimentation rate ; Erythrocytes ; Fibroblasts ; Flow Cytometry ; Growth hormone ; Health risk assessment ; Hospitals ; Humans ; Immunoglobulins ; Immunology ; Indicators ; Infections ; Inflammation ; Longitudinal Studies ; Macrophages ; Medicine ; Monocyte chemoattractant protein 1 ; Patients ; Pentraxins ; Proteins ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Serum Amyloid P-Component - analysis ; Severity of Illness Index</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e55346-e55346</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Liou et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Liou et al 2013 Liou et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c593t-36ade7b06685fa47ae95bec3b56383971ce9cb61b1ccc1bb747d1712225a03123</citedby><cites>FETCH-LOGICAL-c593t-36ade7b06685fa47ae95bec3b56383971ce9cb61b1ccc1bb747d1712225a03123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559534/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559534/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23383162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Frey, Oliver</contributor><creatorcontrib>Liou, Lieh-bang</creatorcontrib><creatorcontrib>Tsai, Wen-pin</creatorcontrib><creatorcontrib>Chang, Chee J</creatorcontrib><creatorcontrib>Chao, Wan-ju</creatorcontrib><creatorcontrib>Chen, Meng-hsin</creatorcontrib><title>Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description><![CDATA[We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfect.
In 111 patients with RA, we examined longitudinal and cross-sectional correlations of blood PTX3, MCP-1, CRP, and ESR levels with measures of clinical arthritic activity, namely, swollen joint count (SJC), tender joint count (TJC), visual analog scale for general health (GH), DAS28, and adapted DAS28-MCP-1.
Blood MCP-1, but not PTX3, was significantly correlated with SJC, TJC, DAS28, and DAS28-CRP. DAS28-MCP-1 was strongly correlated with DAS28 (r = 0.984, P<0.001) and DAS28-CRP (r = 0.971, P<0.001), and modestly correlated with CRP (r = 0.350, P<0.001), and ESR (r = 0.386, P<0.001). Similarly, the duration of arthritic symptoms, but not sex, was significantly correlated with variables of arthritic activity. In particular, DAS28-MCP-1 significantly correlated with DAS28 during a 6-month period (r = 0.944, P<0.001; r = 0.951, P<0.001; r = 0.862, P<0.001; and r = 0.865, P<0.001 for month 0, 1, 3, and 6, respectively).
Blood MCP-1 and adapted DAS28-MCP-1, but not blood PTX3, may be useful in monitoring RA activity.]]></description><subject>Arthritis</subject><subject>Arthritis, Rheumatoid - blood</subject><subject>Arthritis, Rheumatoid - diagnosis</subject><subject>Arthritis, Rheumatoid - pathology</subject><subject>Biology</subject><subject>Biomarkers - blood</subject><subject>Blood</subject><subject>Blood Sedimentation</subject><subject>Blood tests</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - analysis</subject><subject>C-Reactive Protein - metabolism</subject><subject>Chemokine CCL2 - blood</subject><subject>Cross-Sectional Studies</subject><subject>Disease</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Erythrocyte sedimentation rate</subject><subject>Erythrocytes</subject><subject>Fibroblasts</subject><subject>Flow Cytometry</subject><subject>Growth hormone</subject><subject>Health risk assessment</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Indicators</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Longitudinal Studies</subject><subject>Macrophages</subject><subject>Medicine</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Patients</subject><subject>Pentraxins</subject><subject>Proteins</subject><subject>Rheumatoid arthritis</subject><subject>Rheumatoid factor</subject><subject>Rheumatology</subject><subject>Serum Amyloid P-Component - analysis</subject><subject>Severity of Illness Index</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNptUtuO0zAQjRCIXQp_gMASL8tDSmwndswD0lJxWWkRSMCz5cuk9SqJi-1W6lfwy7jbbLVFKz_YHp85M2d8iuIlruaYcvzuxm_CqPr52o8wr6qmoTV7VJxjQUnJSEUf3zufFc9ivMkg2jL2tDgjlLYUM3Je_P3Ye2_R4EdvdgmQWcHgkzLJGbQOPoEbS4wuvi1-lPgtUqNFyqp1Aousi6AioD1269IO_TQ-AGnLW-x71KmtD0r3gNxonVHJh4g6H1BYwWbIV5e5QloFl1w8sjwvnnSqj_Bi2mfF78-ffi2-ltffv1wtLq9L0wiaSsqUBa4rxtqmUzVXIBoNhuqGZWWCYwPCaIY1NsZgrXnNLeaYENKoimJCZ8XrA--691FOs4wSU9JWpGKkzoirA8J6dSPXwQ0q7KRXTt4GfFjK3L4zPUihLaEdx0LTtgYNgumKKMZMp3TNOpO5PkzVNnoAa2BMQfUnpKcvo1vJpd9K2jQif2wmuJgIgv-zgZjk4KKBvlcj-E3um7Q1I7QRe2Vv_oM-rG5CLVUW4MbO57pmTyova84F5Sy7Z1bMH0DlZWFwJhuvczl-klAfEkzwMQbojhpxJfe2vWtG7m0rJ9vmtFf353NMuvMp_QdAdesS</recordid><startdate>20130130</startdate><enddate>20130130</enddate><creator>Liou, Lieh-bang</creator><creator>Tsai, Wen-pin</creator><creator>Chang, Chee J</creator><creator>Chao, Wan-ju</creator><creator>Chen, Meng-hsin</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130130</creationdate><title>Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity</title><author>Liou, Lieh-bang ; Tsai, Wen-pin ; Chang, Chee J ; Chao, Wan-ju ; Chen, Meng-hsin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c593t-36ade7b06685fa47ae95bec3b56383971ce9cb61b1ccc1bb747d1712225a03123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Arthritis</topic><topic>Arthritis, Rheumatoid - blood</topic><topic>Arthritis, Rheumatoid - diagnosis</topic><topic>Arthritis, Rheumatoid - pathology</topic><topic>Biology</topic><topic>Biomarkers - blood</topic><topic>Blood</topic><topic>Blood Sedimentation</topic><topic>Blood tests</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - analysis</topic><topic>C-Reactive Protein - metabolism</topic><topic>Chemokine CCL2 - blood</topic><topic>Cross-Sectional Studies</topic><topic>Disease</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Erythrocyte sedimentation rate</topic><topic>Erythrocytes</topic><topic>Fibroblasts</topic><topic>Flow Cytometry</topic><topic>Growth hormone</topic><topic>Health risk assessment</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Indicators</topic><topic>Infections</topic><topic>Inflammation</topic><topic>Longitudinal Studies</topic><topic>Macrophages</topic><topic>Medicine</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Patients</topic><topic>Pentraxins</topic><topic>Proteins</topic><topic>Rheumatoid arthritis</topic><topic>Rheumatoid factor</topic><topic>Rheumatology</topic><topic>Serum Amyloid P-Component - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liou, Lieh-bang</au><au>Tsai, Wen-pin</au><au>Chang, Chee J</au><au>Chao, Wan-ju</au><au>Chen, Meng-hsin</au><au>Frey, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-30</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e55346</spage><epage>e55346</epage><pages>e55346-e55346</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract><![CDATA[We assessed blood pentraxin 3 (PTX3) and macrophage chemotactic factor-1 (MCP-1) levels as indicators of disease activity in rheumatoid arthritis (RA) patients, because data on disease activity score 28 (DAS28)-erythrocyte sedimentation rate (ESR) and DAS28-C-reactive protein (CRP) are still imperfect.
In 111 patients with RA, we examined longitudinal and cross-sectional correlations of blood PTX3, MCP-1, CRP, and ESR levels with measures of clinical arthritic activity, namely, swollen joint count (SJC), tender joint count (TJC), visual analog scale for general health (GH), DAS28, and adapted DAS28-MCP-1.
Blood MCP-1, but not PTX3, was significantly correlated with SJC, TJC, DAS28, and DAS28-CRP. DAS28-MCP-1 was strongly correlated with DAS28 (r = 0.984, P<0.001) and DAS28-CRP (r = 0.971, P<0.001), and modestly correlated with CRP (r = 0.350, P<0.001), and ESR (r = 0.386, P<0.001). Similarly, the duration of arthritic symptoms, but not sex, was significantly correlated with variables of arthritic activity. In particular, DAS28-MCP-1 significantly correlated with DAS28 during a 6-month period (r = 0.944, P<0.001; r = 0.951, P<0.001; r = 0.862, P<0.001; and r = 0.865, P<0.001 for month 0, 1, 3, and 6, respectively).
Blood MCP-1 and adapted DAS28-MCP-1, but not blood PTX3, may be useful in monitoring RA activity.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23383162</pmid><doi>10.1371/journal.pone.0055346</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Arthritis Arthritis, Rheumatoid - blood Arthritis, Rheumatoid - diagnosis Arthritis, Rheumatoid - pathology Biology Biomarkers - blood Blood Blood Sedimentation Blood tests C-reactive protein C-Reactive Protein - analysis C-Reactive Protein - metabolism Chemokine CCL2 - blood Cross-Sectional Studies Disease Enzyme-Linked Immunosorbent Assay Erythrocyte sedimentation rate Erythrocytes Fibroblasts Flow Cytometry Growth hormone Health risk assessment Hospitals Humans Immunoglobulins Immunology Indicators Infections Inflammation Longitudinal Studies Macrophages Medicine Monocyte chemoattractant protein 1 Patients Pentraxins Proteins Rheumatoid arthritis Rheumatoid factor Rheumatology Serum Amyloid P-Component - analysis Severity of Illness Index |
| title | Blood monocyte chemotactic protein-1 (MCP-1) and adapted disease activity Score28-MCP-1: favorable indicators for rheumatoid arthritis activity |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-24T09%3A20%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Blood%20monocyte%20chemotactic%20protein-1%20(MCP-1)%20and%20adapted%20disease%20activity%20Score28-MCP-1:%20favorable%20indicators%20for%20rheumatoid%20arthritis%20activity&rft.jtitle=PloS%20one&rft.au=Liou,%20Lieh-bang&rft.date=2013-01-30&rft.volume=8&rft.issue=1&rft.spage=e55346&rft.epage=e55346&rft.pages=e55346-e55346&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0055346&rft_dat=%3Cgale_plos_%3EA477937619%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1328020624&rft_id=info:pmid/23383162&rft_galeid=A477937619&rft_doaj_id=oai_doaj_org_article_9bd23f719b384ebe96b02a66cfab46fc&rfr_iscdi=true |