Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus
Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission. Total...
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| creator | Chen, Xiangru Chen, Jie Wen, Jian Xu, Chenyu Zhang, Shu Zhou, Yi-Hua Hu, Yali |
| description | Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission.
Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P |
| doi_str_mv | 10.1371/journal.pone.0055303 |
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Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups.
Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0055303</identifier><identifier>PMID: 23383145</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Antigens ; Antiretroviral drugs ; Babies ; Biology ; Breast ; Breast Feeding ; Breast milk ; Breastfeeding & lactation ; Child ; Child, Preschool ; Children ; Children & youth ; China - epidemiology ; Deoxyribonucleic acid ; DNA ; Drug dosages ; Enzymes ; Globulins ; Gynecology ; Hepatitis ; Hepatitis B ; Hepatitis B - epidemiology ; Hepatitis B - transmission ; Hepatitis B Antigens - blood ; Hepatitis B e antigen ; Hepatitis B surface antigen ; Hepatitis B vaccines ; Hepatitis B virus ; Hospitals ; Humans ; Immunoassay ; Immunoenzyme Techniques ; Immunoglobulins ; Infant ; Infants ; Infections ; Infectious Disease Transmission, Vertical ; Laboratories ; Lesions ; Logistic Models ; Medicine ; Milk ; Mothers ; Obstetrics ; Pregnancy ; Prevalence ; Prevention ; Prophylaxis ; Regression analysis ; Risk Factors ; Statistical analysis ; Vaccination ; Vaccines ; Viruses ; Womens health</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e55303-e55303</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Chen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Chen et al 2013 Chen et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-707a8f8d821ec4ff5aaa331152595d5fd6ac5957e9350c89630ff92131d1df0b3</citedby><cites>FETCH-LOGICAL-c692t-707a8f8d821ec4ff5aaa331152595d5fd6ac5957e9350c89630ff92131d1df0b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557270/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557270/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23383145$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Fung, James</contributor><creatorcontrib>Chen, Xiangru</creatorcontrib><creatorcontrib>Chen, Jie</creatorcontrib><creatorcontrib>Wen, Jian</creatorcontrib><creatorcontrib>Xu, Chenyu</creatorcontrib><creatorcontrib>Zhang, Shu</creatorcontrib><creatorcontrib>Zhou, Yi-Hua</creatorcontrib><creatorcontrib>Hu, Yali</creatorcontrib><title>Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission.
Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups.
Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants.</description><subject>Antigens</subject><subject>Antiretroviral drugs</subject><subject>Babies</subject><subject>Biology</subject><subject>Breast</subject><subject>Breast Feeding</subject><subject>Breast milk</subject><subject>Breastfeeding & lactation</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Children & youth</subject><subject>China - epidemiology</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Globulins</subject><subject>Gynecology</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis B - epidemiology</subject><subject>Hepatitis B - transmission</subject><subject>Hepatitis B Antigens - blood</subject><subject>Hepatitis B e antigen</subject><subject>Hepatitis B surface antigen</subject><subject>Hepatitis B vaccines</subject><subject>Hepatitis B virus</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunoassay</subject><subject>Immunoenzyme Techniques</subject><subject>Immunoglobulins</subject><subject>Infant</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious Disease Transmission, Vertical</subject><subject>Laboratories</subject><subject>Lesions</subject><subject>Logistic Models</subject><subject>Medicine</subject><subject>Milk</subject><subject>Mothers</subject><subject>Obstetrics</subject><subject>Pregnancy</subject><subject>Prevalence</subject><subject>Prevention</subject><subject>Prophylaxis</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Statistical analysis</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Viruses</subject><subject>Womens 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is not a risk factor for mother-to-child transmission of hepatitis B virus</title><author>Chen, Xiangru ; Chen, Jie ; Wen, Jian ; Xu, Chenyu ; Zhang, Shu ; Zhou, Yi-Hua ; Hu, Yali</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-707a8f8d821ec4ff5aaa331152595d5fd6ac5957e9350c89630ff92131d1df0b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Antigens</topic><topic>Antiretroviral drugs</topic><topic>Babies</topic><topic>Biology</topic><topic>Breast</topic><topic>Breast Feeding</topic><topic>Breast milk</topic><topic>Breastfeeding & lactation</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Children & youth</topic><topic>China - epidemiology</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Globulins</topic><topic>Gynecology</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis B - epidemiology</topic><topic>Hepatitis B - transmission</topic><topic>Hepatitis B Antigens - blood</topic><topic>Hepatitis B e antigen</topic><topic>Hepatitis B surface antigen</topic><topic>Hepatitis B vaccines</topic><topic>Hepatitis B virus</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Immunoassay</topic><topic>Immunoenzyme Techniques</topic><topic>Immunoglobulins</topic><topic>Infant</topic><topic>Infants</topic><topic>Infections</topic><topic>Infectious Disease Transmission, Vertical</topic><topic>Laboratories</topic><topic>Lesions</topic><topic>Logistic Models</topic><topic>Medicine</topic><topic>Milk</topic><topic>Mothers</topic><topic>Obstetrics</topic><topic>Pregnancy</topic><topic>Prevalence</topic><topic>Prevention</topic><topic>Prophylaxis</topic><topic>Regression analysis</topic><topic>Risk 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Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Xiangru</au><au>Chen, Jie</au><au>Wen, Jian</au><au>Xu, Chenyu</au><au>Zhang, Shu</au><au>Zhou, Yi-Hua</au><au>Hu, Yali</au><au>Fung, James</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-28</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e55303</spage><epage>e55303</epage><pages>e55303-e55303</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Many clinicians do not encourage breastfeeding in hepatitis B virus (HBV) carriers, since HBV DNA can be detected in breast milk and breast lesions may increase exposure of infants to HBV. The aim of this study was to determine whether breastfeeding may add risk for perinatal HBV transmission.
Totally 546 children (1-7-year-old) of 544 HBV-infected mothers were investigated, with 397 breastfed and 149 formula-fed; 137 were born to HBeAg-positive mothers. All children had been vaccinated against hepatitis B but only 53.3% received hepatitis B immune globulin (HBIG). The overall prevalence of HBsAg+, HBsAg-/anti-HBc+, and anti-HBs (≥10 mIU/ml) in children was 2.4%, 3.1%, and 71.6% respectively. The HBsAg prevalence in breast- and formula-fed children was 1.5% and 4.7% respectively (P = 0.063); the difference was likely due to the higher mothers' HBeAg-positive rate in formula-fed group (formula-fed 49.0% vs. breastfed 15.9%, P<0.001). Further logistic regression analyses showed that breastfeeding was not associated with the HBV infection in the children, adjusting for the effect of maternal HBeAg status and other factors different between the two groups.
Under the recommended prophylaxis, breastfeeding is not a risk factor for mother-to-child transmission of HBV. Therefore, clinicians should encourage HBV-infected mothers to breastfeed their infants.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23383145</pmid><doi>10.1371/journal.pone.0055303</doi><tpages>e55303</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antigens Antiretroviral drugs Babies Biology Breast Breast Feeding Breast milk Breastfeeding & lactation Child Child, Preschool Children Children & youth China - epidemiology Deoxyribonucleic acid DNA Drug dosages Enzymes Globulins Gynecology Hepatitis Hepatitis B Hepatitis B - epidemiology Hepatitis B - transmission Hepatitis B Antigens - blood Hepatitis B e antigen Hepatitis B surface antigen Hepatitis B vaccines Hepatitis B virus Hospitals Humans Immunoassay Immunoenzyme Techniques Immunoglobulins Infant Infants Infections Infectious Disease Transmission, Vertical Laboratories Lesions Logistic Models Medicine Milk Mothers Obstetrics Pregnancy Prevalence Prevention Prophylaxis Regression analysis Risk Factors Statistical analysis Vaccination Vaccines Viruses Womens health |
| title | Breastfeeding is not a risk factor for mother-to-child transmission of hepatitis B virus |
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