Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study
Arsenic in drinking water was associated with increased risk of all-cause, cancer, and cardiovascular death in adults. However, the extent to which exposure is related to all-cause and deaths from cancer and cardiovascular condition in young age is unknown. Therefore, we prospectively assessed wheth...
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| Veröffentlicht in: | PloS one 2013-01, Vol.8 (1), p.e55014 |
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| description | Arsenic in drinking water was associated with increased risk of all-cause, cancer, and cardiovascular death in adults. However, the extent to which exposure is related to all-cause and deaths from cancer and cardiovascular condition in young age is unknown. Therefore, we prospectively assessed whether long-term and recent arsenic exposures are associated with all-cause and cancer and cardiovascular mortalities in Bangladeshi childhood population.
We assembled a cohort of 58406 children aged 5-18 years from the Health and Demographic Surveillance System of icddrb in Bangladesh and followed during 2003-2010. There were 185 non-accidental deaths registered in-about 0.4 million person-years of observation. We calculated hazard ratios for cause-specific death in relation to exposure at baseline (µg/L), time-weighted lifetime average (µg/L) and cumulative concentration (µg-years/L). After adjusting covariates, hazard ratios (HRs) for all-cause childhood deaths comparing lifetime average exposure 10-50.0, 50.1-150.0, 150.1-300.0 and ≥300.1µg/L were 1.37 (95% confidence interval [CI], 0.74-2.57), 1.44 (95% CI, 0.88-2.38), 1.22 (95% CI, 0.75-1.98) and 1.88 (95% CI, 1.14-3.10) respectively. Significant increased risk was also observed for baseline (P for trend = 0.023) and cumulative exposure categories (P for trend = 0.036). Girls had higher mortality risk compared to boys (HR for girls 1.79, 1.21, 1.64, 2.31; HR for boys 0.52, 0.53, 1.14, 0.99) in relation to baseline exposure. For all cancers and cardiovascular deaths combined, multivariable adjusted HRs amounted to 1.53 (95% CI 0.51-4.57); 1.29 (95% CI 0.43-3.87); 2.18 (95%CI 1.15-4.16) for 10.0-50.0, 50.1-150.0, and ≥150.1, comparing lowest exposure as reference (P for trend = 0.009). Adolescents had higher mortality risk compared to children (HRs = 1.53, 95% CI 1.03-2.28 vs. HRs = 1.30, 95% CI 0.78-2.17).
Arsenic exposure was associated with substantial increased risk of deaths at young age from all-cause, and cancers and cardiovascular conditions. Girls and adolescents (12-18 years) had higher risk compared to boys and child. |
| doi_str_mv | 10.1371/journal.pone.0055014 |
| format | Article |
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We assembled a cohort of 58406 children aged 5-18 years from the Health and Demographic Surveillance System of icddrb in Bangladesh and followed during 2003-2010. There were 185 non-accidental deaths registered in-about 0.4 million person-years of observation. We calculated hazard ratios for cause-specific death in relation to exposure at baseline (µg/L), time-weighted lifetime average (µg/L) and cumulative concentration (µg-years/L). After adjusting covariates, hazard ratios (HRs) for all-cause childhood deaths comparing lifetime average exposure 10-50.0, 50.1-150.0, 150.1-300.0 and ≥300.1µg/L were 1.37 (95% confidence interval [CI], 0.74-2.57), 1.44 (95% CI, 0.88-2.38), 1.22 (95% CI, 0.75-1.98) and 1.88 (95% CI, 1.14-3.10) respectively. Significant increased risk was also observed for baseline (P for trend = 0.023) and cumulative exposure categories (P for trend = 0.036). Girls had higher mortality risk compared to boys (HR for girls 1.79, 1.21, 1.64, 2.31; HR for boys 0.52, 0.53, 1.14, 0.99) in relation to baseline exposure. For all cancers and cardiovascular deaths combined, multivariable adjusted HRs amounted to 1.53 (95% CI 0.51-4.57); 1.29 (95% CI 0.43-3.87); 2.18 (95%CI 1.15-4.16) for 10.0-50.0, 50.1-150.0, and ≥150.1, comparing lowest exposure as reference (P for trend = 0.009). Adolescents had higher mortality risk compared to children (HRs = 1.53, 95% CI 1.03-2.28 vs. HRs = 1.30, 95% CI 0.78-2.17).
Arsenic exposure was associated with substantial increased risk of deaths at young age from all-cause, and cancers and cardiovascular conditions. Girls and adolescents (12-18 years) had higher risk compared to boys and child.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0055014</identifier><identifier>PMID: 23383038</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adolescents ; Adult ; Adults ; Analysis ; Arsenic ; Arsenic - analysis ; Arsenic - toxicity ; Bangladesh - epidemiology ; Biology ; Cancer ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - mortality ; Child ; Child health ; Child, Preschool ; Childhood ; Children ; Cohort analysis ; Cohort Studies ; Confidence intervals ; Demographics ; Drinking water ; Drinking Water - chemistry ; Environmental Exposure - statistics & numerical data ; Epidemiology ; Exposure ; Fatalities ; Female ; Girls ; Health risk assessment ; Health risks ; Humans ; Male ; Medicine ; Mortality ; Mortality risk ; Neoplasms - chemically induced ; Neoplasms - mortality ; Population studies ; Population-based studies ; Risk ; Risk Assessment ; Rural Population - statistics & numerical data ; Teenagers ; Time Factors ; Youth</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e55014</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Rahman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Rahman et al 2013 Rahman et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-26bd20547af09b3c7b2e57cae5f1f606df05fc46ed14a9a385e535ad1f9278d63</citedby><cites>FETCH-LOGICAL-c758t-26bd20547af09b3c7b2e57cae5f1f606df05fc46ed14a9a385e535ad1f9278d63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557245/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3557245/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23383038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>States, J. Christopher</contributor><creatorcontrib>Rahman, Mahfuzar</creatorcontrib><creatorcontrib>Sohel, Nazmul</creatorcontrib><creatorcontrib>Yunus, Mohammad</creatorcontrib><creatorcontrib>Chowdhury, Mahbub Elahi</creatorcontrib><creatorcontrib>Hore, Samar Kumar</creatorcontrib><creatorcontrib>Zaman, Khalequ</creatorcontrib><creatorcontrib>Bhuiya, Abbas</creatorcontrib><creatorcontrib>Streatfield, Peter Kim</creatorcontrib><title>Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Arsenic in drinking water was associated with increased risk of all-cause, cancer, and cardiovascular death in adults. However, the extent to which exposure is related to all-cause and deaths from cancer and cardiovascular condition in young age is unknown. Therefore, we prospectively assessed whether long-term and recent arsenic exposures are associated with all-cause and cancer and cardiovascular mortalities in Bangladeshi childhood population.
We assembled a cohort of 58406 children aged 5-18 years from the Health and Demographic Surveillance System of icddrb in Bangladesh and followed during 2003-2010. There were 185 non-accidental deaths registered in-about 0.4 million person-years of observation. We calculated hazard ratios for cause-specific death in relation to exposure at baseline (µg/L), time-weighted lifetime average (µg/L) and cumulative concentration (µg-years/L). After adjusting covariates, hazard ratios (HRs) for all-cause childhood deaths comparing lifetime average exposure 10-50.0, 50.1-150.0, 150.1-300.0 and ≥300.1µg/L were 1.37 (95% confidence interval [CI], 0.74-2.57), 1.44 (95% CI, 0.88-2.38), 1.22 (95% CI, 0.75-1.98) and 1.88 (95% CI, 1.14-3.10) respectively. Significant increased risk was also observed for baseline (P for trend = 0.023) and cumulative exposure categories (P for trend = 0.036). Girls had higher mortality risk compared to boys (HR for girls 1.79, 1.21, 1.64, 2.31; HR for boys 0.52, 0.53, 1.14, 0.99) in relation to baseline exposure. For all cancers and cardiovascular deaths combined, multivariable adjusted HRs amounted to 1.53 (95% CI 0.51-4.57); 1.29 (95% CI 0.43-3.87); 2.18 (95%CI 1.15-4.16) for 10.0-50.0, 50.1-150.0, and ≥150.1, comparing lowest exposure as reference (P for trend = 0.009). Adolescents had higher mortality risk compared to children (HRs = 1.53, 95% CI 1.03-2.28 vs. HRs = 1.30, 95% CI 0.78-2.17).
Arsenic exposure was associated with substantial increased risk of deaths at young age from all-cause, and cancers and cardiovascular conditions. Girls and adolescents (12-18 years) had higher risk compared to boys and child.</description><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Adults</subject><subject>Analysis</subject><subject>Arsenic</subject><subject>Arsenic - analysis</subject><subject>Arsenic - toxicity</subject><subject>Bangladesh - epidemiology</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cardiovascular Diseases - chemically induced</subject><subject>Cardiovascular Diseases - mortality</subject><subject>Child</subject><subject>Child health</subject><subject>Child, Preschool</subject><subject>Childhood</subject><subject>Children</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Confidence intervals</subject><subject>Demographics</subject><subject>Drinking water</subject><subject>Drinking Water - chemistry</subject><subject>Environmental Exposure - statistics & numerical data</subject><subject>Epidemiology</subject><subject>Exposure</subject><subject>Fatalities</subject><subject>Female</subject><subject>Girls</subject><subject>Health risk assessment</subject><subject>Health risks</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Mortality</subject><subject>Mortality risk</subject><subject>Neoplasms - chemically induced</subject><subject>Neoplasms - mortality</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Risk</subject><subject>Risk Assessment</subject><subject>Rural Population - statistics & numerical data</subject><subject>Teenagers</subject><subject>Time Factors</subject><subject>Youth</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNkluLFDEQhRtR3HX1H4g2CILgjEmn0xcfhHXxMrCy4O01VOfSnTGTjElanX9vxuldpkFB8pBQ-c6pojhZ9hCjJSY1frF2o7dglltn5RIhShEub2WnuCXFoioQuX30PsnuhbBOEGmq6m52UhDSEESa08yvLPcSghQ5H7QRg3Mi3zgfwei4y8GKHHyQVvNc21x4bb9p2-c_IUq_r3yAaKB7nr8G2xsQMgwvc8i3bjsaiNrZRXfwdkPyzEMcxe5-dkeBCfLBdJ9lX96--XzxfnF59W51cX654DVt4qKoOlEgWtagUNsRXneFpDUHSRVWFaqEQlTxspICl9ACaaikhILAqi3qRlTkLHt88N0aF9i0rsAwKeq2bosSJWJ1IISDNdt6vQG_Yw40-1Nwvmfgo-ZGsrpBXaGkULhBZVehpFeqw20JVHJo991eTd3GbiMFlzZ6MDPT-Y_VA-vdD0YorYuSJoMnk4F330cZ4j9Gnqge0lTaKpfM-EYHzs7Lum6ripQkUcu_UOkIudE8BUbpVJ8Jns0EiYnyV-xhDIGtPn38f_bq65x9esQOEkwcgjPjPhphDpYHkHsXgpfqZnMYsX3er7fB9nlnU96T7NHx1m9E1wEnvwE-rvxr</recordid><startdate>20130128</startdate><enddate>20130128</enddate><creator>Rahman, Mahfuzar</creator><creator>Sohel, Nazmul</creator><creator>Yunus, Mohammad</creator><creator>Chowdhury, Mahbub Elahi</creator><creator>Hore, Samar Kumar</creator><creator>Zaman, Khalequ</creator><creator>Bhuiya, Abbas</creator><creator>Streatfield, Peter Kim</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130128</creationdate><title>Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study</title><author>Rahman, Mahfuzar ; Sohel, Nazmul ; Yunus, Mohammad ; Chowdhury, Mahbub Elahi ; Hore, Samar Kumar ; Zaman, Khalequ ; Bhuiya, Abbas ; Streatfield, Peter Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-26bd20547af09b3c7b2e57cae5f1f606df05fc46ed14a9a385e535ad1f9278d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Adults</topic><topic>Analysis</topic><topic>Arsenic</topic><topic>Arsenic - 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Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rahman, Mahfuzar</au><au>Sohel, Nazmul</au><au>Yunus, Mohammad</au><au>Chowdhury, Mahbub Elahi</au><au>Hore, Samar Kumar</au><au>Zaman, Khalequ</au><au>Bhuiya, Abbas</au><au>Streatfield, Peter Kim</au><au>States, J. Christopher</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-28</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e55014</spage><pages>e55014-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Arsenic in drinking water was associated with increased risk of all-cause, cancer, and cardiovascular death in adults. However, the extent to which exposure is related to all-cause and deaths from cancer and cardiovascular condition in young age is unknown. Therefore, we prospectively assessed whether long-term and recent arsenic exposures are associated with all-cause and cancer and cardiovascular mortalities in Bangladeshi childhood population.
We assembled a cohort of 58406 children aged 5-18 years from the Health and Demographic Surveillance System of icddrb in Bangladesh and followed during 2003-2010. There were 185 non-accidental deaths registered in-about 0.4 million person-years of observation. We calculated hazard ratios for cause-specific death in relation to exposure at baseline (µg/L), time-weighted lifetime average (µg/L) and cumulative concentration (µg-years/L). After adjusting covariates, hazard ratios (HRs) for all-cause childhood deaths comparing lifetime average exposure 10-50.0, 50.1-150.0, 150.1-300.0 and ≥300.1µg/L were 1.37 (95% confidence interval [CI], 0.74-2.57), 1.44 (95% CI, 0.88-2.38), 1.22 (95% CI, 0.75-1.98) and 1.88 (95% CI, 1.14-3.10) respectively. Significant increased risk was also observed for baseline (P for trend = 0.023) and cumulative exposure categories (P for trend = 0.036). Girls had higher mortality risk compared to boys (HR for girls 1.79, 1.21, 1.64, 2.31; HR for boys 0.52, 0.53, 1.14, 0.99) in relation to baseline exposure. For all cancers and cardiovascular deaths combined, multivariable adjusted HRs amounted to 1.53 (95% CI 0.51-4.57); 1.29 (95% CI 0.43-3.87); 2.18 (95%CI 1.15-4.16) for 10.0-50.0, 50.1-150.0, and ≥150.1, comparing lowest exposure as reference (P for trend = 0.009). Adolescents had higher mortality risk compared to children (HRs = 1.53, 95% CI 1.03-2.28 vs. HRs = 1.30, 95% CI 0.78-2.17).
Arsenic exposure was associated with substantial increased risk of deaths at young age from all-cause, and cancers and cardiovascular conditions. Girls and adolescents (12-18 years) had higher risk compared to boys and child.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23383038</pmid><doi>10.1371/journal.pone.0055014</doi><tpages>e55014</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-01, Vol.8 (1), p.e55014 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1327979240 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Public Library of Science (PLoS); PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adolescent Adolescents Adult Adults Analysis Arsenic Arsenic - analysis Arsenic - toxicity Bangladesh - epidemiology Biology Cancer Cardiovascular Diseases - chemically induced Cardiovascular Diseases - mortality Child Child health Child, Preschool Childhood Children Cohort analysis Cohort Studies Confidence intervals Demographics Drinking water Drinking Water - chemistry Environmental Exposure - statistics & numerical data Epidemiology Exposure Fatalities Female Girls Health risk assessment Health risks Humans Male Medicine Mortality Mortality risk Neoplasms - chemically induced Neoplasms - mortality Population studies Population-based studies Risk Risk Assessment Rural Population - statistics & numerical data Teenagers Time Factors Youth |
| title | Increased childhood mortality and arsenic in drinking water in Matlab, Bangladesh: a population-based cohort study |
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