Relationship between LTR methylation and gag expression of HIV-1 in human spermatozoa and sperm-derived embryos

Studying the methylation status of long terminal repeats (LTR) and its relationship to gag expression of HIV-1 in order to explore regulation mechanism of HIV-1 gene expression in vertical transmission from sperm to embryo. Sperm samples were collected from a healthy donor and seven patients with HI...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54801-e54801
Hauptverfasser:	Li, FangZheng, Li, LianBing, Zhong, Ying, Xie, QingDong, Huang, JiHua, Kang, XiangJin, Wang, Dian, Xu, Lan, Huang, TianHua
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Biology Bisulfite CpG islands Cricetinae Deoxyribonucleic acid Disease transmission DNA DNA Methylation Embryonic development Embryos Female Fertilization gag Gene Products, Human Immunodeficiency Virus - genetics Gag protein Gene Expression Gene Expression Regulation, Viral Genes Genomes Hepatitis HIV HIV Infections - metabolism HIV Infections - virology HIV Long Terminal Repeat - genetics HIV patients HIV-1 - genetics Human immunodeficiency virus Humans In vitro fertilization Infectious diseases Interspecific Laboratories Male Mammals Maternal & child health Medicine Methylation Ova Patients Plasmids Polymerase chain reaction Protein Biosynthesis Reproductive health Sampling methods Sperm Spermatogenesis Spermatozoa Spermatozoa - metabolism Stem cells Sulfites Transcription, Genetic Transfection Viruses Zygote - metabolism Zygotes
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