Endoxifen's molecular mechanisms of action are concentration dependent and different than that of other anti-estrogens

Endoxifen, a cytochrome P450 mediated tamoxifen metabolite, is being developed as a drug for the treatment of estrogen receptor (ER) positive breast cancer. Endoxifen is known to be a potent anti-estrogen and its mechanisms of action are still being elucidated. Here, we demonstrate that endoxifen-me...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54613
Hauptverfasser:	Hawse, John R, Subramaniam, Malayannan, Cicek, Muzaffer, Wu, Xianglin, Gingery, Anne, Grygo, Sarah B, Sun, Zhifu, Pitel, Kevin S, Lingle, Wilma L, Goetz, Matthew P, Ingle, James N, Spelsberg, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antiestrogens Apoptosis Biochemistry Bioinformatics Biology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cell cycle Cell Cycle - drug effects Cell growth Cell Line, Tumor Chromatin Immunoprecipitation Cluster Analysis Cytochrome Cytochrome P450 Estrogen Antagonists - metabolism Estrogen Antagonists - pharmacology Estrogen Receptor alpha - antagonists & inhibitors Estrogen Receptor alpha - metabolism Estrogen receptors Estrogens Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic - drug effects Genes Humans Ligands Medicine Metabolism Metabolites Molecular biology Molecular modelling Protein Binding Reproducibility of Results Response Elements RNA polymerase Signal Transduction - drug effects Tamoxifen Tamoxifen - analogs & derivatives Tamoxifen - metabolism Tamoxifen - pharmacology
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