The spectrum of SWI/SNF mutations, ubiquitous in human cancers

SWI/SNF is a multi-subunit chromatin remodeling complex that uses the energy of ATP hydrolysis to reposition nucleosomes, thereby modulating gene expression. Accumulating evidence suggests that SWI/SNF functions as a tumor suppressor in some cancers. However, the spectrum of SWI/SNF mutations across...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e55119-e55119
Hauptverfasser:	Shain, A Hunter, Pollack, Jonathan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Biology Breast cancer Cancer Chromatin Chromatin remodeling Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Data Mining Deoxyribonucleic acid DNA Energy consumption Enzymes Epigenetics Exome Gastric cancer Gene expression Genes Genetic aspects Humans Medicine Mutation Neoplasms - genetics Neoplasms - metabolism Nucleosomes p53 Protein Pancreatic cancer Proteins Stem cells Stomach cancer Transcription Factors - genetics Transcription Factors - metabolism Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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