Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization

Amyloid fibrils of α-synuclein are the main constituent of Lewy bodies deposited in substantial nigra of Parkinson's disease brains. α-Synuclein is an intrinsically disordered protein lacking compact secondary and tertiary structures. To enhance the understanding of its structure and function r...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53487
Hauptverfasser:	Ariesandi, Winny, Chang, Chi-Fon, Chen, Tseng-Erh, Chen, Yun-Ru
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - chemistry alpha-Synuclein - genetics Alzheimer's disease Amino acids Amyloid Biochemistry Biology Biophysics Circular dichroism Crosslinking Dichroism Dopamine E coli Fibrillogenesis Fibrils Fourier transforms Genomics High temperature Humans Kinetics Lewy bodies Medicine Movement disorders Mutation Neurodegenerative diseases NMR Nuclear magnetic resonance Oligomers Parkinson Disease - metabolism Parkinson's disease Physics Physiology Protein Denaturation Protein expression Protein Multimerization Protein seeding Protein Structure, Secondary Proteins Sequence Deletion Structure-function relationships Synuclein Temperature Temperature effects Ultracentrifugation
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