Timing of umbilical cord blood derived mesenchymal stem cells transplantation determines therapeutic efficacy in the neonatal hyperoxic lung injury

Intratracheal transplantation of human umbilical cord blood (UCB)-derived mesenchymal stem cells (MSCs) attenuates the hyperoxia-induced neonatal lung injury. The aim of this study was to optimize the timing of MSCs transplantation. Newborn Sprague-Dawley rats were randomly exposed to hyperoxia (90%...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e52419
Hauptverfasser:	Chang, Yun Sil, Choi, Soo Jin, Ahn, So Yoon, Sung, Dong Kyung, Sung, Se In, Yoo, Hye Soo, Oh, Won Il, Park, Won Soon
Format:	Artikel
Sprache:	eng
Schlagworte:	Adhesion tests Alveoli Animals Animals, Newborn Apoptosis Attenuation Bioindicators Biology Biomedical research Blood Body Weight Cell adhesion Cell Membrane - metabolism Collagen Collagen - metabolism Cord blood Cytokines Cytokines - metabolism Cytosol - metabolism Enzyme-linked immunosorbent assay Experiments Female Fetal Blood - cytology Gene Expression Regulation Growth factors Health aspects Hepatocyte growth factor Hepatocyte Growth Factor - metabolism Humans Hyperoxia Hyperoxia - complications Inflammation Injuries Intercellular adhesion molecule 1 Interleukin 6 L-selectin Laboratory animals Lung diseases Lung Injury - complications Lung Injury - metabolism Lung Injury - pathology Lung Injury - surgery Macrophages Medical research Medicine Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - cytology Mesenchyme Metalloproteinase NADPH Oxidases - metabolism Neonates Newborn babies Newborn infants Oxidative stress Pediatrics Peroxidase Peroxidase - metabolism Pregnancy Protein arrays Pulmonary arteries RANTES Rats Rats, Sprague-Dawley Rodents Stem cell transplantation Stem cells Survival Rate Time Factors Transforming growth factor-b Transplantation Tumor necrosis factor-TNF Umbilical cord Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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