Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination
The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood. We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF5...
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| Veröffentlicht in: | PloS one 2013, Vol.8 (1), p.e54890-e54890 |
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| creator | Huijskens, Elisabeth G W Reimerink, Johan Mulder, Paul G H van Beek, Janko Meijer, Adam de Bruin, Erwin Friesema, Ingrid de Jong, Menno D Rimmelzwaan, Guus F Peeters, Marcel F Rossen, John W A Koopmans, Marion |
| description | The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.
We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity. |
| doi_str_mv | 10.1371/journal.pone.0054890 |
| format | Article |
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We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0054890</identifier><identifier>PMID: 23365683</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Animals ; Antibodies ; Antibodies, Viral - biosynthesis ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Antibody response ; Antigens ; Avian flu ; Avian influenza ; Biology ; Birds ; Care and treatment ; Comparative analysis ; Diagnostic systems ; Female ; Health aspects ; Hemagglutination inhibition ; Hemagglutination Inhibition Tests ; Hemagglutinin Glycoproteins, Influenza Virus - blood ; Hemagglutinin Glycoproteins, Influenza Virus - immunology ; Humans ; Immune response (humoral) ; Immunity ; Infections ; Influenza ; Influenza A ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza in Birds - immunology ; Influenza in Birds - virology ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - blood ; Influenza, Human - immunology ; Influenza, Human - prevention & control ; Influenza, Human - virology ; Laboratories ; Male ; Medicine ; Middle Aged ; Pandemics ; Protein Array Analysis ; Protein arrays ; Protein microarrays ; Risk factors ; Seasons ; Vaccination ; Vaccination - methods ; Vaccination - statistics & numerical data ; Vaccines ; Viruses</subject><ispartof>PloS one, 2013, Vol.8 (1), p.e54890-e54890</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Huijskens et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Huijskens et al 2013 Huijskens et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c557t-19e32c8a6bdfb4c80594401ca093198166739b61fd47f365bddc00fafe2df9ae3</citedby><cites>FETCH-LOGICAL-c557t-19e32c8a6bdfb4c80594401ca093198166739b61fd47f365bddc00fafe2df9ae3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554683/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554683/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,4010,23845,27900,27901,27902,53766,53768,79343,79344</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23365683$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Huijskens, Elisabeth G W</creatorcontrib><creatorcontrib>Reimerink, Johan</creatorcontrib><creatorcontrib>Mulder, Paul G H</creatorcontrib><creatorcontrib>van Beek, Janko</creatorcontrib><creatorcontrib>Meijer, Adam</creatorcontrib><creatorcontrib>de Bruin, Erwin</creatorcontrib><creatorcontrib>Friesema, Ingrid</creatorcontrib><creatorcontrib>de Jong, Menno D</creatorcontrib><creatorcontrib>Rimmelzwaan, Guus F</creatorcontrib><creatorcontrib>Peeters, Marcel F</creatorcontrib><creatorcontrib>Rossen, John W A</creatorcontrib><creatorcontrib>Koopmans, Marion</creatorcontrib><title>Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.
We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Viral - biosynthesis</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Antibody response</subject><subject>Antigens</subject><subject>Avian flu</subject><subject>Avian influenza</subject><subject>Biology</subject><subject>Birds</subject><subject>Care and treatment</subject><subject>Comparative analysis</subject><subject>Diagnostic systems</subject><subject>Female</subject><subject>Health aspects</subject><subject>Hemagglutination inhibition</subject><subject>Hemagglutination Inhibition Tests</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - blood</subject><subject>Hemagglutinin Glycoproteins, Influenza Virus - immunology</subject><subject>Humans</subject><subject>Immune response (humoral)</subject><subject>Immunity</subject><subject>Infections</subject><subject>Influenza</subject><subject>Influenza A</subject><subject>Influenza A Virus, H1N1 Subtype - immunology</subject><subject>Influenza in Birds - immunology</subject><subject>Influenza in Birds - virology</subject><subject>Influenza vaccines</subject><subject>Influenza Vaccines - administration & dosage</subject><subject>Influenza Vaccines - immunology</subject><subject>Influenza, Human - blood</subject><subject>Influenza, Human - immunology</subject><subject>Influenza, Human - prevention & control</subject><subject>Influenza, Human - virology</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Protein Array Analysis</subject><subject>Protein arrays</subject><subject>Protein microarrays</subject><subject>Risk factors</subject><subject>Seasons</subject><subject>Vaccination</subject><subject>Vaccination - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Huijskens, Elisabeth G W</au><au>Reimerink, Johan</au><au>Mulder, Paul G H</au><au>van Beek, Janko</au><au>Meijer, Adam</au><au>de Bruin, Erwin</au><au>Friesema, Ingrid</au><au>de Jong, Menno D</au><au>Rimmelzwaan, Guus F</au><au>Peeters, Marcel F</au><au>Rossen, John W A</au><au>Koopmans, Marion</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e54890</spage><epage>e54890</epage><pages>e54890-e54890</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The influence of prior seasonal influenza vaccination on the antibody response produced by natural infection or vaccination is not well understood.
We compared the profiles of antibody responses of 32 naturally infected subjects and 98 subjects vaccinated with a 2009 influenza A(H1N1) monovalent MF59-adjuvanted vaccine (Focetria, Novartis), with and without a history of seasonal influenza vaccination. Antibodies were measured by hemagglutination inhibition (HI) assay for influenza A(H1N1)pdm09 and by protein microarray (PA) using the HA1 subunit for seven recent and historic H1, H2 and H3 influenza viruses, and three avian influenza viruses. Serum samples for the infection group were taken at the moment of collection of the diagnostic sample, 10 days and 30 days after onset of influenza symptoms. For the vaccination group, samples were drawn at baseline, 3 weeks after the first vaccination and 5 weeks after the second vaccination.
We showed that subjects with a history of seasonal vaccination generally exhibited higher baseline titers for the various HA1 antigens than subjects without a seasonal vaccination history. Infection and pandemic influenza vaccination responses in persons with a history of seasonal vaccination were skewed towards historic antigens.
Seasonal vaccination is of significant influence on the antibody response to subsequent infection and vaccination, and further research is needed to understand the effect of annual vaccination on protective immunity.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23365683</pmid><doi>10.1371/journal.pone.0054890</doi><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_plos_journals_1327892829 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adolescent Adult Aged Animals Antibodies Antibodies, Viral - biosynthesis Antibodies, Viral - blood Antibodies, Viral - immunology Antibody response Antigens Avian flu Avian influenza Biology Birds Care and treatment Comparative analysis Diagnostic systems Female Health aspects Hemagglutination inhibition Hemagglutination Inhibition Tests Hemagglutinin Glycoproteins, Influenza Virus - blood Hemagglutinin Glycoproteins, Influenza Virus - immunology Humans Immune response (humoral) Immunity Infections Influenza Influenza A Influenza A Virus, H1N1 Subtype - immunology Influenza in Birds - immunology Influenza in Birds - virology Influenza vaccines Influenza Vaccines - administration & dosage Influenza Vaccines - immunology Influenza, Human - blood Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Laboratories Male Medicine Middle Aged Pandemics Protein Array Analysis Protein arrays Protein microarrays Risk factors Seasons Vaccination Vaccination - methods Vaccination - statistics & numerical data Vaccines Viruses |
| title | Profiling of humoral response to influenza A(H1N1)pdm09 infection and vaccination measured by a protein microarray in persons with and without history of seasonal vaccination |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T15%3A47%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Profiling%20of%20humoral%20response%20to%20influenza%20A(H1N1)pdm09%20infection%20and%20vaccination%20measured%20by%20a%20protein%20microarray%20in%20persons%20with%20and%20without%20history%20of%20seasonal%20vaccination&rft.jtitle=PloS%20one&rft.au=Huijskens,%20Elisabeth%20G%20W&rft.date=2013&rft.volume=8&rft.issue=1&rft.spage=e54890&rft.epage=e54890&rft.pages=e54890-e54890&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0054890&rft_dat=%3Cgale_plos_%3EA478023281%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327892829&rft_id=info:pmid/23365683&rft_galeid=A478023281&rft_doaj_id=oai_doaj_org_article_6ddec03a52f74a5e9755c7e313dea3cd&rfr_iscdi=true |