Astrocytes enhance the invasion potential of glioblastoma stem-like cells

Glioblastomas (GBMs) are characterized as highly invasive; the contribution of GBM stem-like cells (GSCs) to the invasive phenotype, however, has not been completely defined. Towards this end, we have defined the invasion potential of CD133+ GSCs and their differentiated CD133- counterparts grown un...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54752-e54752
Hauptverfasser:	Rath, Barbara H, Fair, Joshlean M, Jamal, Muhammad, Camphausen, Kevin, Tofilon, Philip J
Format:	Artikel
Sprache:	eng
Schlagworte:	AC133 Antigen Antigens, CD - metabolism Astrocytes Astrocytes - cytology Astrocytes - metabolism Biology Brain Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - pathology Cancer therapies Cell culture Cell cycle Cell Differentiation Cell growth Cell Line, Tumor Chemokines Chemotherapy Conditioning Culture Media, Conditioned - metabolism Culture Media, Conditioned - pharmacology Cytokines Experiments Gene expression Genes Glioblastoma Glioblastoma - metabolism Glioblastoma - pathology Glycoproteins - metabolism Growth factors Humans Medicine Microscopy, Electron, Scanning Transmission Monolayers Monomolecular films Neoplasm Invasiveness - pathology Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology Peptides - metabolism Progeny Radiation therapy Secretome Stem cells Transcriptome Tumor Microenvironment
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