Bisphenol A accelerates toxic amyloid formation of human islet amyloid polypeptide: a possible link between bisphenol A exposure and type 2 diabetes

Bisphenol A (BPA) is a chemical compound widely used in manufacturing plastic products. Recent epidemiological studies suggest BPA exposure is positively associated with the incidence of type 2 diabetes mellitus (T2DM), however the mechanisms underlying this link remain unclear. Human islet amyloid...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54198
Hauptverfasser:	Gong, Hao, Zhang, Xin, Cheng, Biao, Sun, Yue, Li, Chuanzhou, Li, Ting, Zheng, Ling, Huang, Kun
Format:	Artikel
Sprache:	eng
Schlagworte:	Agglomeration Air Pollutants, Occupational - toxicity Amino Acid Sequence Amylin Amyloid Animals Apoptosis Benzhydryl Compounds - toxicity Benzothiazoles Biochemistry Biology Bisphenol A Cell death Cell Line, Tumor Cell Membrane - chemistry Cell Membrane - drug effects Chromatography Circular Dichroism Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - pathology Dichroism Disease Dose-Response Relationship, Drug Epidemiology Exposure Fibrils Fluorescence Fluorescence microscopy Glycerol Homeostasis Humans Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology Islet Amyloid Polypeptide - analysis Islet Amyloid Polypeptide - chemical synthesis Islet Amyloid Polypeptide - ultrastructure Kinases Life sciences Light scattering Mathematics Medicine Microscopy Microscopy, Electron, Transmission Molecular Sequence Annotation Oligomers Oxidative Stress Oxygen Pancreas Pancreatic beta cells Pharmacy Phenols Phenols (Class of compounds) Phenols - toxicity Photon correlation spectroscopy Physiology Plastics Polypeptides Protein Folding - drug effects Protein Structure, Secondary Proteins Rats Reactive oxygen species Rodents Spectrum analysis Thiazoles Type 2 diabetes
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