The different role of Notch1 and Notch2 in astrocytic gliomas

It is well known that Notch signaling plays either oncogenic or tumor suppressive role in a variety of tumors, depending on the cellular context. However, in our previous study, we found that Notch1 was overexpressed while Notch2 downregulated in the majority of astrocytic gliomas with different gra...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53654
Hauptverfasser:	Xu, Peng, Zhang, Anling, Jiang, Rongcai, Qiu, Mingzhe, Kang, Chunsheng, Jia, Zhifan, Wang, Guangxiu, Han, Lei, Fan, Xing, Pu, Peiyu
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Animals Apoptosis Astrocytoma - metabolism Astrocytoma - pathology Biological activity Biology Brain cancer Brain tumors Cell Line, Tumor Cell Proliferation Cell Transformation, Neoplastic Development and progression Education Epidermal growth factor receptors Female Gene Knockdown Techniques Glioblastoma Glioblastoma cells Glioma Glioma cells Gliomas Humans In vivo methods and tests Kinases Laboratories Leukemia Medicine Mice Neoplasm Invasiveness Nervous system Neurosurgery Notch protein Notch1 protein Notch2 protein Pathogenesis Phosphatidylinositol 3-Kinases - metabolism Plasmids - genetics Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - metabolism Receptor, Notch1 - deficiency Receptor, Notch1 - genetics Receptor, Notch1 - metabolism Receptor, Notch2 - deficiency Receptor, Notch2 - genetics Receptor, Notch2 - metabolism RNA, Small Interfering - genetics Signal Transduction Signaling siRNA Stem cells Transfection Trauma Tumorigenesis Tumors Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!