Plexin A3 and turnout regulate motor axonal branch morphogenesis in zebrafish

During embryogenesis motor axons navigate to their target muscles, where individual motor axons develop complex branch morphologies. The mechanisms that control axonal branching morphogenesis have been studied intensively, yet it still remains unclear when branches begin to form or how branch locati...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54071-e54071
Hauptverfasser:	Sainath, Rajiv, Granato, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Axon guidance Axonogenesis Axons Axons - metabolism Axons - physiology Bifurcations Biology Cell adhesion & migration Danio rerio Defects Dendritic branching Developmental biology Embryo, Nonmammalian - embryology Embryo, Nonmammalian - innervation Embryo, Nonmammalian - metabolism Embryogenesis Embryonic development Embryonic growth stage Extracellular Matrix - metabolism Gene mapping Genetic screening Genetic testing Green Fluorescent Proteins - genetics Green Fluorescent Proteins - metabolism Immunohistochemistry Kinases Microscopy, Confocal Morphogenesis Morphogenesis - genetics Motor neurons Motor Neurons - metabolism Motor Neurons - physiology Muscle Fibers, Skeletal - metabolism Muscle, Skeletal - embryology Muscle, Skeletal - innervation Muscle, Skeletal - metabolism Muscles Mutants Mutation Neurogenesis - genetics Neurons Open reading frames Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Rodents Spinal cord Synapses - metabolism Synapses - physiology Zebrafish Zebrafish - embryology Zebrafish - genetics Zebrafish - metabolism Zebrafish Proteins - genetics Zebrafish Proteins - metabolism
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