The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line

Telomeres distinguish chromosome ends from double-strand breaks (DSBs) and prevent chromosome fusion. However, telomeres can also interfere with DNA repair, as shown by a deficiency in nonhomologous end joining (NHEJ) and an increase in large deletions at telomeric DSBs. The sensitivity of telomeric...

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Veröffentlicht in:	PLoS genetics 2013-03, Vol.9 (3), p.e1003386
Hauptverfasser:	Muraki, Keiko, Han, Limei, Miller, Douglas, Murnane, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Mutated Proteins Biology Cancer Cancer cells Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell lines Chromosomal Instability - genetics Chromosome Aberrations Chromosomes DNA Breaks, Double-Stranded DNA End-Joining Repair - genetics DNA repair DNA Repair - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genetic aspects Genetics Health aspects Humans Medicine Neoplasms - genetics Neoplasms - metabolism Physiological aspects Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Proteins Sequence Deletion - genetics Telomere - genetics Telomeres Telomeric Repeat Binding Protein 2 - genetics Telomeric Repeat Binding Protein 2 - metabolism Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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