Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions

Essentially all biological processes depend on protein-protein interactions (PPIs). Timing of such interactions is crucial for regulatory function. Although circadian (~24-hour) clocks constitute fundamental cellular timing mechanisms regulating important physiological processes, PPI dynamics on thi...

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Veröffentlicht in:	PLoS genetics 2013-03, Vol.9 (3), p.e1003398-e1003398
Hauptverfasser:	Wallach, Thomas, Schellenberg, Katja, Maier, Bert, Kalathur, Ravi Kiran Reddy, Porras, Pablo, Wanker, Erich E, Futschik, Matthias E, Kramer, Achim
Format:	Artikel
Sprache:	eng
Schlagworte:	ARNTL Transcription Factors - genetics ARNTL Transcription Factors - metabolism Biological clocks Biology Cell cycle Cell Cycle - genetics Cell Cycle - physiology Cell interaction Circadian Clocks - genetics Circadian rhythm Circadian Rhythm - genetics Circadian rhythms CLOCK Proteins - genetics CLOCK Proteins - metabolism ErbB Receptors - metabolism Experiments Genetic aspects Health aspects HEK293 Cells Humans Kinases Physiological aspects Protein Interaction Maps - genetics Protein Phosphatase 1 - genetics Protein Phosphatase 1 - metabolism Protein-protein interactions Proteins Regulation Signal Transduction
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