The conserved SKN-1/Nrf2 stress response pathway regulates synaptic function in Caenorhabditis elegans

The Nrf family of transcription factors plays a critical role in mediating adaptive responses to cellular stress and defends against neurodegeneration, aging, and cancer. Here, we report a novel role for the Caenorhabditis elegans Nrf homolog SKN-1 in regulating synaptic transmission at neuromuscula...

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Veröffentlicht in:	PLoS genetics 2013-03, Vol.9 (3), p.e1003354-e1003354
Hauptverfasser:	Staab, Trisha A, Griffen, Trevor C, Corcoran, Connor, Evgrafov, Oleg, Knowles, James A, Sieburth, Derek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arsenites - pharmacology Biology Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans - physiology Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Cell Nucleus - genetics Cell Nucleus - metabolism Cullin Proteins DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Genetic aspects Genetics Genomics Mitochondrial Membranes - drug effects Mutation Nervous System - drug effects Nervous System - metabolism Neural circuitry Neurodegeneration Neuromuscular Junction - genetics Neuromuscular Junction - physiology Observations Oxidative stress Oxidative Stress - drug effects Properties Proteins Sodium Compounds - pharmacology Stress response Synapses Synaptic Transmission - genetics Synaptic Transmission - physiology Testing Transcription factors Transcription Factors - genetics Transcription Factors - metabolism
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