Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions

The TRAIL (TNF-related apoptosis inducing ligand) death receptors (DRs) of the tumor necrosis factor receptor superfamily (TNFRSF) can promote apoptosis and regulate antiviral immunity by maintaining immune homeostasis during infection. In turn, human cytomegalovirus (HCMV) expresses immunomodulator...

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Veröffentlicht in:	PLoS pathogens 2013-03, Vol.9 (3), p.e1003224-e1003224
Hauptverfasser:	Nemčovičová, Ivana, Benedict, Chris A, Zajonc, Dirk M
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Binding Sites Binding sites (Biochemistry) Biology Crystal structure Cytomegalovirus Cytomegalovirus - chemistry Cytomegalovirus - metabolism Cytomegaloviruses Death Domain Receptor Signaling Adaptor Proteins - chemistry Death Domain Receptor Signaling Adaptor Proteins - metabolism Health aspects Homeostasis Host-Pathogen Interactions Humans Immune Evasion - genetics Immune system Immunomodulation Ligands Ligands (Biochemistry) Microbiology Mutation Physiological aspects Protein Binding Protein Folding Protein Structure, Tertiary Proteins Receptors, Death Domain - chemistry Receptors, Death Domain - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - chemistry Receptors, TNF-Related Apoptosis-Inducing Ligand - genetics Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism
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