Serotonin receptor 2C and insulin secretion

Type 2 diabetes mellitus (T2DM) describes a group of metabolic disorders characterized by defects in insulin secretion and insulin sensitivity. Insulin secretion from pancreatic β-cells is an important factor in the etiology of T2DM, though the complex regulation and mechanisms of insulin secretion...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54250
Hauptverfasser:	Zhang, Qiang, Zhu, Yunxia, Zhou, Wenbo, Gao, Lu, Yuan, Li, Han, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Amino acids Aminopyridines - pharmacology Animals Biology Biosynthesis Blotting, Western Body temperature Brain Cell Line, Tumor Defects Development and progression Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Dopamine Dose-Response Relationship, Drug Etiology Gene expression Gene Expression - drug effects Genomics Glucose Homeostasis Humans Indoles - pharmacology Insulin Insulin - metabolism Insulin resistance Insulin Secretion Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Interference Islets of Langerhans - drug effects Islets of Langerhans - metabolism Laboratories Male Medicine Metabolic disorders Metabolism Mice Mice, Inbred C57BL Mice, Inbred ICR Nervous system Neurons Palmitic acid Palmitic Acid - pharmacology Pancreas Pancreatic beta cells Phenols (Class of compounds) Piperazines - pharmacology Plasma levels Receptor, Serotonin, 5-HT2C - genetics Receptor, Serotonin, 5-HT2C - metabolism Reproductive health Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA Interference RNA-mediated interference Rodents Saturated fatty acids Secretion Serotonin Serotonin 5-HT2 Receptor Antagonists - pharmacology Serotonin Receptor Agonists - pharmacology Serotonin S2 receptors Signaling Studies Therapeutic applications Type 2 diabetes
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