A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics

Serratia plymuthica strain RVH1, initially isolated from an industrial food processing environment, displays potent antimicrobial activity towards a broad spectrum of Gram-positive and Gram-negative bacterial pathogens. Isolation and subsequent structure determination of bioactive molecules led to t...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e54143
Hauptverfasser:	Masschelein, Joleen, Mattheus, Wesley, Gao, Ling-Jie, Moons, Pieter, Van Houdt, Rob, Uytterhoeven, Birgit, Lamberigts, Chris, Lescrinier, Eveline, Rozenski, Jef, Herdewijn, Piet, Aertsen, Abram, Michiels, Chris, Lavigne, Rob
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics Antimicrobial activity Antimicrobial agents Architecture Artificial chromosomes Assembly lines Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Biochemistry Biofilms Biology Biosynthesis Chemical compounds Chemistry Cloning, Molecular Clusters DNA Transposable Elements - genetics Drugs Enzymes Experiments Fatty Acid Synthases - genetics Fatty Acid Synthases - metabolism Fatty acids Fermentation Food Food industry Food processing Food processing industry Gene Fusion Gene Order Genes Genetic engineering Gram-negative bacteria Homology Laboratories Macrolides - chemistry Macrolides - metabolism Macrolides - pharmacology Magnetic Resonance Spectroscopy Mass Spectrometry - methods Metabolites Molecular Sequence Data Molecular Structure Multigene Family Mutagenesis, Insertional Peptide Synthases - genetics Peptide Synthases - metabolism Peptides Pharmaceutical sciences Physiological aspects Polyamines - chemistry Polyamines - metabolism Polyamines - pharmacology Polyketide Synthases - genetics Polyketide Synthases - metabolism Polyunsaturated fatty acids Prodrugs Sequence Analysis, DNA Sequence Homology, Amino Acid Serratia Serratia - genetics Serratia - metabolism Staphylococcus aureus - drug effects Staphylococcus aureus - growth & development Unsaturated fatty acids Vibrio cholerae
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