Association study of 25 type 2 diabetes related Loci with measures of obesity in Indian sib pairs

Obesity is an established risk factor for type 2 diabetes (T2D) and they are metabolically related through the mechanism of insulin resistance. In order to explore how common genetic variants associated with T2D correlate with body mass index (BMI), we examined the influence of 25 T2D associated loc...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e53944-e53944
Hauptverfasser:	Gupta, Vipin, Vinay, Donipadi Guru, Sovio, Ulla, Rafiq, Sajjad, Kranthi Kumar, Madamchetty Venkata, Janipalli, Charles Spurgeon, Evans, David, Mani, Kulathu Radha, Sandeep, Madana Narasimha, Taylor, Amy, Kinra, Sanjay, Sullivan, Ruth, Bowen, Liza, Timpson, Nicholas, Smith, George Davey, Dudbridge, Frank, Prabhakaran, Dorairaj, Ben-Shlomo, Yoav, Reddy, Kolli Srinath, Ebrahim, Shah, Chandak, Giriraj Ratan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Basic Helix-Loop-Helix Transcription Factors - genetics Biology Body fat Body mass Body Mass Index Body size Body weight Body Weight - genetics Cardiovascular disease Chronic illnesses Councils CXCR4 protein Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Energy consumption Epidemiology Exercise Factories Female Gene Frequency Genetic aspects Genetic diversity Genetic Predisposition to Disease - genetics Genetic variance Genomes Genotype Health risks Hepatocyte Nuclear Factor 3-beta - genetics Hip Homeodomain Proteins - genetics Humans Hygiene India Industrial research Insulin Insulin resistance Loci Male Mediation Medicine Migration Molecular biology Neoplasm Proteins - genetics Nerve Tissue Proteins - genetics Obesity Obesity - complications Obesity - genetics Overweight Physical activity Polymorphism, Single Nucleotide Population Public health Receptors, CXCR4 - genetics Risk factors Siblings Studies Transcription Factor 7-Like 2 Protein - genetics Transcription Factors - genetics Transients and Migrants - statistics & numerical data Type 2 diabetes Waist-Hip Ratio
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