Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands
Genovar distributions of Chlamydia trachomatis based on ompA typing differ between men who have sex with men (MSM) and heterosexuals. We investigated clonal relationships using a high resolution typing method to characterize C. trachomatis types in these two risk groups. C. trachomatis positive samp...
Gespeichert in:
| Veröffentlicht in: | PloS one 2013-01, Vol.8 (1), p.e53869-e53869 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e53869 |
|---|---|
| container_issue | 1 |
| container_start_page | e53869 |
| container_title | PloS one |
| container_volume | 8 |
| creator | Bom, Reinier J M van der Helm, Jannie J Schim van der Loeff, Maarten F van Rooijen, Martijn S Heijman, Titia Matser, Amy de Vries, Henry J C Bruisten, Sylvia M |
| description | Genovar distributions of Chlamydia trachomatis based on ompA typing differ between men who have sex with men (MSM) and heterosexuals. We investigated clonal relationships using a high resolution typing method to characterize C. trachomatis types in these two risk groups.
C. trachomatis positive samples were collected at the STI outpatient clinic in Amsterdam between 2008 and 2010 and genotyped by multilocus sequence typing. Clusters were assigned using minimum spanning trees and these were combined with epidemiological data of the hosts.
We typed 526 C. trachomatis positive samples: 270 from MSM and 256 from heterosexuals. Eight clusters, containing 10-128 samples were identified of which 4 consisted of samples from MSM (90%-100%), with genovars D, G, J, and L2b. The other 4 clusters consisted mainly of samples from heterosexuals (87%-100%) with genovars D, E, F, I, and J. Genetic diversity was much lower in the MSM clusters than in heterosexual clusters. Significant differences in number of sexual partners and HIV-serostatus were observed for MSM-associated clusters.
C. trachomatis transmission patterns among MSM and heterosexuals were largely distinct. We hypothesize that these differences are due to sexual host behavior, but bacterial factors may play a role as well. |
| doi_str_mv | 10.1371/journal.pone.0053869 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1327254375</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A478256072</galeid><doaj_id>oai_doaj_org_article_abd3d9a81868487195ff9127ecf01dc4</doaj_id><sourcerecordid>A478256072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-bea413a6a1b8e57f79f6601957e247db92bf3a32d0a21cc2f43095eaa390464d3</originalsourceid><addsrcrecordid>eNqNk1tv0zAUxyMEYmPwDRBYmoRAosW3xMkLUlVulSYmweDVOo1PGo8kLrGzbl-BT4172dSiPaA8ODr-_f-2zyVJnjM6ZkKxd5du6DtoxkvX4ZjSVORZ8SA5ZoXgo4xT8XDv_yh54v3lFsoeJ0dcCMkpT4-TPx-sD7YrAwk9dL613lvXkQ7DyvW_PHEVmdYNtDfGwhopa9dCsJ7YjrTYkVXtSA1XSDxek5UN9SYKnSE1BuxdDA_QEDBDEzaiSetj3ED7llzUSL5iqLFvosA_TR5V0Hh8tltPkh-fPl5Mv4zOzj_PppOzUZkVPIzmCJIJyIDNc0xVpYoqyygrUoVcKjMv-LwSILihwFlZ8koKWqQIIAoqM2nESfJy67tsnNe7NHrNBFc8lUKlkZhtCePgUi9720J_ox1YvQm4fqGhD7ZsUMPcCFNAzvIsl7mK16iqgnGFZUWZKWX0er87bZi3aErsYhabA9PDnc7WeuGutEilojKPBq93Br37PaAPOhapxCbmDN0Q782VyGla8DV6-g96_-t21ALiA2xXuXVd16Z6IlXO04wqHqnxPVT8DLa2jD1X2Rg_ELw5EEQm4HVYwOC9nn3_9v_s-c9D9tUeWyM0ofauGULsU38Iyi1YxrbzPVZ3SWZUr0fmNht6PTJ6NzJR9mK_QHei2xkRfwGS3hLl</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1327254375</pqid></control><display><type>article</type><title>Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><source>Public Library of Science (PLoS)</source><creator>Bom, Reinier J M ; van der Helm, Jannie J ; Schim van der Loeff, Maarten F ; van Rooijen, Martijn S ; Heijman, Titia ; Matser, Amy ; de Vries, Henry J C ; Bruisten, Sylvia M</creator><creatorcontrib>Bom, Reinier J M ; van der Helm, Jannie J ; Schim van der Loeff, Maarten F ; van Rooijen, Martijn S ; Heijman, Titia ; Matser, Amy ; de Vries, Henry J C ; Bruisten, Sylvia M</creatorcontrib><description>Genovar distributions of Chlamydia trachomatis based on ompA typing differ between men who have sex with men (MSM) and heterosexuals. We investigated clonal relationships using a high resolution typing method to characterize C. trachomatis types in these two risk groups.
C. trachomatis positive samples were collected at the STI outpatient clinic in Amsterdam between 2008 and 2010 and genotyped by multilocus sequence typing. Clusters were assigned using minimum spanning trees and these were combined with epidemiological data of the hosts.
We typed 526 C. trachomatis positive samples: 270 from MSM and 256 from heterosexuals. Eight clusters, containing 10-128 samples were identified of which 4 consisted of samples from MSM (90%-100%), with genovars D, G, J, and L2b. The other 4 clusters consisted mainly of samples from heterosexuals (87%-100%) with genovars D, E, F, I, and J. Genetic diversity was much lower in the MSM clusters than in heterosexual clusters. Significant differences in number of sexual partners and HIV-serostatus were observed for MSM-associated clusters.
C. trachomatis transmission patterns among MSM and heterosexuals were largely distinct. We hypothesize that these differences are due to sexual host behavior, but bacterial factors may play a role as well.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0053869</identifier><identifier>PMID: 23342025</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Adults ; Ambulatory care facilities ; Bacteria ; Bacterial Outer Membrane Proteins - genetics ; Biology ; Chlamydia ; Chlamydia Infections - epidemiology ; Chlamydia Infections - transmission ; Chlamydia trachomatis ; Chlamydia trachomatis - classification ; Chlamydia trachomatis - genetics ; Chlamydia trachomatis - physiology ; Clusters ; Condoms ; Epidemiology ; Female ; Genetic diversity ; Genomes ; Genotype ; Graph theory ; Health services ; Hepatitis ; Heterosexuality - statistics & numerical data ; Homosexuality, Male - statistics & numerical data ; Humans ; Immunology ; Infections ; Laboratories ; Male ; Medicine ; Men ; Mens health ; Middle Aged ; Multilocus sequence typing ; Netherlands - epidemiology ; Population ; Public health ; Risk ; Risk groups ; Sex ; Sexual behavior ; Sexual partners ; Sexually transmitted diseases ; STD ; Studies ; Urine ; Women ; Young Adult</subject><ispartof>PloS one, 2013-01, Vol.8 (1), p.e53869-e53869</ispartof><rights>COPYRIGHT 2013 Public Library of Science</rights><rights>2013 Bom et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Bom et al 2013 Bom et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-bea413a6a1b8e57f79f6601957e247db92bf3a32d0a21cc2f43095eaa390464d3</citedby><cites>FETCH-LOGICAL-c692t-bea413a6a1b8e57f79f6601957e247db92bf3a32d0a21cc2f43095eaa390464d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547048/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3547048/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,2915,23845,27901,27902,53766,53768,79569,79570</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23342025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bom, Reinier J M</creatorcontrib><creatorcontrib>van der Helm, Jannie J</creatorcontrib><creatorcontrib>Schim van der Loeff, Maarten F</creatorcontrib><creatorcontrib>van Rooijen, Martijn S</creatorcontrib><creatorcontrib>Heijman, Titia</creatorcontrib><creatorcontrib>Matser, Amy</creatorcontrib><creatorcontrib>de Vries, Henry J C</creatorcontrib><creatorcontrib>Bruisten, Sylvia M</creatorcontrib><title>Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Genovar distributions of Chlamydia trachomatis based on ompA typing differ between men who have sex with men (MSM) and heterosexuals. We investigated clonal relationships using a high resolution typing method to characterize C. trachomatis types in these two risk groups.
C. trachomatis positive samples were collected at the STI outpatient clinic in Amsterdam between 2008 and 2010 and genotyped by multilocus sequence typing. Clusters were assigned using minimum spanning trees and these were combined with epidemiological data of the hosts.
We typed 526 C. trachomatis positive samples: 270 from MSM and 256 from heterosexuals. Eight clusters, containing 10-128 samples were identified of which 4 consisted of samples from MSM (90%-100%), with genovars D, G, J, and L2b. The other 4 clusters consisted mainly of samples from heterosexuals (87%-100%) with genovars D, E, F, I, and J. Genetic diversity was much lower in the MSM clusters than in heterosexual clusters. Significant differences in number of sexual partners and HIV-serostatus were observed for MSM-associated clusters.
C. trachomatis transmission patterns among MSM and heterosexuals were largely distinct. We hypothesize that these differences are due to sexual host behavior, but bacterial factors may play a role as well.</description><subject>Adult</subject><subject>Adults</subject><subject>Ambulatory care facilities</subject><subject>Bacteria</subject><subject>Bacterial Outer Membrane Proteins - genetics</subject><subject>Biology</subject><subject>Chlamydia</subject><subject>Chlamydia Infections - epidemiology</subject><subject>Chlamydia Infections - transmission</subject><subject>Chlamydia trachomatis</subject><subject>Chlamydia trachomatis - classification</subject><subject>Chlamydia trachomatis - genetics</subject><subject>Chlamydia trachomatis - physiology</subject><subject>Clusters</subject><subject>Condoms</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genomes</subject><subject>Genotype</subject><subject>Graph theory</subject><subject>Health services</subject><subject>Hepatitis</subject><subject>Heterosexuality - statistics & numerical data</subject><subject>Homosexuality, Male - statistics & numerical data</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Men</subject><subject>Mens health</subject><subject>Middle Aged</subject><subject>Multilocus sequence typing</subject><subject>Netherlands - epidemiology</subject><subject>Population</subject><subject>Public health</subject><subject>Risk</subject><subject>Risk groups</subject><subject>Sex</subject><subject>Sexual behavior</subject><subject>Sexual partners</subject><subject>Sexually transmitted diseases</subject><subject>STD</subject><subject>Studies</subject><subject>Urine</subject><subject>Women</subject><subject>Young Adult</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNqNk1tv0zAUxyMEYmPwDRBYmoRAosW3xMkLUlVulSYmweDVOo1PGo8kLrGzbl-BT4172dSiPaA8ODr-_f-2zyVJnjM6ZkKxd5du6DtoxkvX4ZjSVORZ8SA5ZoXgo4xT8XDv_yh54v3lFsoeJ0dcCMkpT4-TPx-sD7YrAwk9dL613lvXkQ7DyvW_PHEVmdYNtDfGwhopa9dCsJ7YjrTYkVXtSA1XSDxek5UN9SYKnSE1BuxdDA_QEDBDEzaiSetj3ED7llzUSL5iqLFvosA_TR5V0Hh8tltPkh-fPl5Mv4zOzj_PppOzUZkVPIzmCJIJyIDNc0xVpYoqyygrUoVcKjMv-LwSILihwFlZ8koKWqQIIAoqM2nESfJy67tsnNe7NHrNBFc8lUKlkZhtCePgUi9720J_ox1YvQm4fqGhD7ZsUMPcCFNAzvIsl7mK16iqgnGFZUWZKWX0er87bZi3aErsYhabA9PDnc7WeuGutEilojKPBq93Br37PaAPOhapxCbmDN0Q782VyGla8DV6-g96_-t21ALiA2xXuXVd16Z6IlXO04wqHqnxPVT8DLa2jD1X2Rg_ELw5EEQm4HVYwOC9nn3_9v_s-c9D9tUeWyM0ofauGULsU38Iyi1YxrbzPVZ3SWZUr0fmNht6PTJ6NzJR9mK_QHei2xkRfwGS3hLl</recordid><startdate>20130116</startdate><enddate>20130116</enddate><creator>Bom, Reinier J M</creator><creator>van der Helm, Jannie J</creator><creator>Schim van der Loeff, Maarten F</creator><creator>van Rooijen, Martijn S</creator><creator>Heijman, Titia</creator><creator>Matser, Amy</creator><creator>de Vries, Henry J C</creator><creator>Bruisten, Sylvia M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PIMPY</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130116</creationdate><title>Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands</title><author>Bom, Reinier J M ; van der Helm, Jannie J ; Schim van der Loeff, Maarten F ; van Rooijen, Martijn S ; Heijman, Titia ; Matser, Amy ; de Vries, Henry J C ; Bruisten, Sylvia M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-bea413a6a1b8e57f79f6601957e247db92bf3a32d0a21cc2f43095eaa390464d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Adults</topic><topic>Ambulatory care facilities</topic><topic>Bacteria</topic><topic>Bacterial Outer Membrane Proteins - genetics</topic><topic>Biology</topic><topic>Chlamydia</topic><topic>Chlamydia Infections - epidemiology</topic><topic>Chlamydia Infections - transmission</topic><topic>Chlamydia trachomatis</topic><topic>Chlamydia trachomatis - classification</topic><topic>Chlamydia trachomatis - genetics</topic><topic>Chlamydia trachomatis - physiology</topic><topic>Clusters</topic><topic>Condoms</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Genetic diversity</topic><topic>Genomes</topic><topic>Genotype</topic><topic>Graph theory</topic><topic>Health services</topic><topic>Hepatitis</topic><topic>Heterosexuality - statistics & numerical data</topic><topic>Homosexuality, Male - statistics & numerical data</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicine</topic><topic>Men</topic><topic>Mens health</topic><topic>Middle Aged</topic><topic>Multilocus sequence typing</topic><topic>Netherlands - epidemiology</topic><topic>Population</topic><topic>Public health</topic><topic>Risk</topic><topic>Risk groups</topic><topic>Sex</topic><topic>Sexual behavior</topic><topic>Sexual partners</topic><topic>Sexually transmitted diseases</topic><topic>STD</topic><topic>Studies</topic><topic>Urine</topic><topic>Women</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bom, Reinier J M</creatorcontrib><creatorcontrib>van der Helm, Jannie J</creatorcontrib><creatorcontrib>Schim van der Loeff, Maarten F</creatorcontrib><creatorcontrib>van Rooijen, Martijn S</creatorcontrib><creatorcontrib>Heijman, Titia</creatorcontrib><creatorcontrib>Matser, Amy</creatorcontrib><creatorcontrib>de Vries, Henry J C</creatorcontrib><creatorcontrib>Bruisten, Sylvia M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bom, Reinier J M</au><au>van der Helm, Jannie J</au><au>Schim van der Loeff, Maarten F</au><au>van Rooijen, Martijn S</au><au>Heijman, Titia</au><au>Matser, Amy</au><au>de Vries, Henry J C</au><au>Bruisten, Sylvia M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-01-16</date><risdate>2013</risdate><volume>8</volume><issue>1</issue><spage>e53869</spage><epage>e53869</epage><pages>e53869-e53869</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Genovar distributions of Chlamydia trachomatis based on ompA typing differ between men who have sex with men (MSM) and heterosexuals. We investigated clonal relationships using a high resolution typing method to characterize C. trachomatis types in these two risk groups.
C. trachomatis positive samples were collected at the STI outpatient clinic in Amsterdam between 2008 and 2010 and genotyped by multilocus sequence typing. Clusters were assigned using minimum spanning trees and these were combined with epidemiological data of the hosts.
We typed 526 C. trachomatis positive samples: 270 from MSM and 256 from heterosexuals. Eight clusters, containing 10-128 samples were identified of which 4 consisted of samples from MSM (90%-100%), with genovars D, G, J, and L2b. The other 4 clusters consisted mainly of samples from heterosexuals (87%-100%) with genovars D, E, F, I, and J. Genetic diversity was much lower in the MSM clusters than in heterosexual clusters. Significant differences in number of sexual partners and HIV-serostatus were observed for MSM-associated clusters.
C. trachomatis transmission patterns among MSM and heterosexuals were largely distinct. We hypothesize that these differences are due to sexual host behavior, but bacterial factors may play a role as well.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23342025</pmid><doi>10.1371/journal.pone.0053869</doi><tpages>e53869</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2013-01, Vol.8 (1), p.e53869-e53869 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1327254375 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free Full-Text Journals in Chemistry; Public Library of Science (PLoS) |
| subjects | Adult Adults Ambulatory care facilities Bacteria Bacterial Outer Membrane Proteins - genetics Biology Chlamydia Chlamydia Infections - epidemiology Chlamydia Infections - transmission Chlamydia trachomatis Chlamydia trachomatis - classification Chlamydia trachomatis - genetics Chlamydia trachomatis - physiology Clusters Condoms Epidemiology Female Genetic diversity Genomes Genotype Graph theory Health services Hepatitis Heterosexuality - statistics & numerical data Homosexuality, Male - statistics & numerical data Humans Immunology Infections Laboratories Male Medicine Men Mens health Middle Aged Multilocus sequence typing Netherlands - epidemiology Population Public health Risk Risk groups Sex Sexual behavior Sexual partners Sexually transmitted diseases STD Studies Urine Women Young Adult |
| title | Distinct transmission networks of Chlamydia trachomatis in men who have sex with men and heterosexual adults in Amsterdam, The Netherlands |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-20T20%3A23%3A13IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Distinct%20transmission%20networks%20of%20Chlamydia%20trachomatis%20in%20men%20who%20have%20sex%20with%20men%20and%20heterosexual%20adults%20in%20Amsterdam,%20The%20Netherlands&rft.jtitle=PloS%20one&rft.au=Bom,%20Reinier%20J%20M&rft.date=2013-01-16&rft.volume=8&rft.issue=1&rft.spage=e53869&rft.epage=e53869&rft.pages=e53869-e53869&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0053869&rft_dat=%3Cgale_plos_%3EA478256072%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327254375&rft_id=info:pmid/23342025&rft_galeid=A478256072&rft_doaj_id=oai_doaj_org_article_abd3d9a81868487195ff9127ecf01dc4&rfr_iscdi=true |