Investigating the antiproliferative activity of high affinity DNA aptamer on cancer cells

Vascular endothelial growth factor (VEGF) is an angiogenic mitogen involved in promoting tumor angiogenesis inside the body. VEGF is a key protein required for progression of tumor from benign to malignant phenotype. In this study, we investigated the binding affinity of a previously selected 26-mer...

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Veröffentlicht in:	PloS one 2013-01, Vol.8 (1), p.e50964-e50964
Hauptverfasser:	Kaur, Harleen, Li, Jasmine J, Bay, Boon-Huat, Yung, Lin-Yue Lanry
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Angiogenesis Annexin A5 - metabolism Anticoagulants Antiproliferatives Apoptosis Aptamers Aptamers, Nucleotide - metabolism Aptamers, Nucleotide - pharmacology Aptamers, Nucleotide - therapeutic use Base Sequence Binding Biocompatibility Biology Blotting, Western Calcium-Binding Proteins - metabolism Cancer Cancer cells Cancer genetics Cancer therapies Cell Extracts Cell growth Cell Proliferation - drug effects Chemistry Circular Dichroism Deoxyribonucleases - metabolism Deoxyribonucleic acid Dichroism DNA Drug Screening Assays, Antitumor Flow Cytometry Hep G2 Cells Heparin Humans Hypoxia Immobilized Proteins - metabolism Intercellular Signaling Peptides and Proteins - metabolism Jagged-1 Protein Kinases Kinetics Linkages Medicine Membrane Proteins - metabolism Neoplasms - drug therapy Neoplasms - pathology Notch protein Nucleotide sequence Organothiophosphorus Compounds - metabolism Phosphorothioate Protein Binding - drug effects Rodents Serrate-Jagged Proteins Serum Signal transduction Signaling Spectroscopy Surface Plasmon Resonance Vascular endothelial growth factor Vascular Endothelial Growth Factor A - metabolism
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