Preparation and efficacy of a live newcastle disease virus vaccine encapsulated in chitosan nanoparticles

Newcastle disease (ND) is a highly contagious viral disease of poultry caused by pathogenic strains of the Newcastle disease virus (NDV). Live NDV vaccines are administered by drinking water, eyedrops or coarse aerosol spray. To further enhance mucosal immune responses, chitosan nanoparticles were d...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e53314
Hauptverfasser:	Zhao, Kai, Chen, Gang, Shi, Xing-Ming, Gao, Ting-Ting, Li, Wei, Zhao, Yan, Zhang, Feng-Qiang, Wu, Jin, Cui, Xianlan, Wang, Yun-Feng
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animal vaccines Animals Antigens Biology Biotechnology Cells, Cultured Chick Embryo Chickens Chickens - immunology Chitosan Chitosan - adverse effects Chitosan - chemistry Chitosan - pharmacology Crosslinking Deoxyribonucleic acid DNA Drinking water Drug Compounding - methods Drug delivery systems Drug development Drugs Encapsulation Engineering Ethics Immune response Immunization Immunosuppressive agents Infections Infectious diseases Laboratory animals Life sciences Materials Science Medicine Mucosal immunity Nanoparticles Nanoparticles - adverse effects Nanoparticles - chemistry Newcastle disease Newcastle Disease - immunology Newcastle Disease - prevention & control Newcastle disease virus - immunology Peptides Polymer crosslinking Polymers Poultry Poultry Diseases - immunology Poultry Diseases - prevention & control Proteins Random Allocation Specific pathogen free Structural proteins Treatment Outcome Vaccination - adverse effects Vaccination - methods Vaccination - veterinary Vaccines Vaccines, Attenuated - adverse effects Vaccines, Attenuated - biosynthesis Vaccines, Attenuated - chemistry Vaccines, Attenuated - therapeutic use Veterinary Science Viral Vaccines - adverse effects Viral Vaccines - biosynthesis Viral Vaccines - chemistry Viral Vaccines - therapeutic use Virulence (Microbiology) Viruses Western blotting Zeta potential
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