Clinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008
A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical man...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e52986-e52986 |
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| creator | Roddy, Paul Howard, Natasha Van Kerkhove, Maria D Lutwama, Julius Wamala, Joseph Yoti, Zabulon Colebunders, Robert Palma, Pedro Pablo Sterk, Esther Jeffs, Benjamin Van Herp, Michel Borchert, Matthias |
| description | A confirmed Ebola haemorrhagic fever (EHF) outbreak in Bundibugyo, Uganda, November 2007-February 2008, was caused by a putative new species (Bundibugyo ebolavirus). It included 93 putative cases, 56 laboratory-confirmed cases, and 37 deaths (CFR = 25%). Study objectives are to describe clinical manifestations and case management for 26 hospitalised laboratory-confirmed EHF patients. Clinical findings are congruous with previously reported EHF infections. The most frequently experienced symptoms were non-bloody diarrhoea (81%), severe headache (81%), and asthenia (77%). Seven patients reported or were observed with haemorrhagic symptoms, six of whom died. Ebola care remains difficult due to the resource-poor setting of outbreaks and the infection-control procedures required. However, quality data collection is essential to evaluate case definitions and therapeutic interventions, and needs improvement in future epidemics. Organizations usually involved in EHF case management have a particular responsibility in this respect. |
| doi_str_mv | 10.1371/journal.pone.0052986 |
| format | Article |
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| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-12, Vol.7 (12), p.e52986-e52986 |
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| source | Public Library of Science (PLoS) Journals Open Access; MEDLINE; EZB Free E-Journals; DOAJ Directory of Open Access Journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Adult Aged Asthenia Biology Case Management Cohort Studies Data collection Departments Diarrhea Disease control Disease Outbreaks - statistics & numerical data Ebola virus Ebolavirus Ebolavirus - classification Ebolavirus - isolation & purification Epidemics Epidemiology Extremely high frequencies Fatalities Female Fever Headache Health aspects Hemorrhagic fever Hemorrhagic Fever, Ebola - diagnosis Hemorrhagic Fever, Ebola - epidemiology Hemorrhagic Fever, Ebola - therapy Hemorrhagic Fever, Ebola - virology Humans Hygiene Infection Control - methods Infections Infectious diseases Laboratories Male Management Marburg virus disease Medical research Medicine Middle Aged New species Outbreaks Patients Therapeutic applications Uganda - epidemiology Viral diseases Viral infections Viruses Young Adult |
| title | Clinical manifestations and case management of Ebola haemorrhagic fever caused by a newly identified virus strain, Bundibugyo, Uganda, 2007-2008 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T19%3A03%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20manifestations%20and%20case%20management%20of%20Ebola%20haemorrhagic%20fever%20caused%20by%20a%20newly%20identified%20virus%20strain,%20Bundibugyo,%20Uganda,%202007-2008&rft.jtitle=PloS%20one&rft.au=Roddy,%20Paul&rft.date=2012-12-28&rft.volume=7&rft.issue=12&rft.spage=e52986&rft.epage=e52986&rft.pages=e52986-e52986&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0052986&rft_dat=%3Cgale_plos_%3EA477013652%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327231838&rft_id=info:pmid/23285243&rft_galeid=A477013652&rft_doaj_id=oai_doaj_org_article_6f6e9369517f4baa93ec779988586c15&rfr_iscdi=true |