Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database
Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus. We examined a large-scale hospital administrative database consisting of...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e53224-e53224 |
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| creator | Urushihara, Hisashi Taketsuna, Masanori Liu, Ying Oda, Eisei Nakamura, Masaki Nishiuma, Shinichi Maeda, Rei |
| description | Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus.
We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; the odds ratios associated with diabetes mellitus and other comorbid risk factors were estimated with separate case-control analyses. In cohort analysis, the incidence of acute pancreatitis was higher in 14,707 diabetic patients than in 186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P |
| doi_str_mv | 10.1371/journal.pone.0053224 |
| format | Article |
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We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; the odds ratios associated with diabetes mellitus and other comorbid risk factors were estimated with separate case-control analyses. In cohort analysis, the incidence of acute pancreatitis was higher in 14,707 diabetic patients than in 186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P<0.001) compared with non-diabetic patients in case-control analysis from 1,372 cases and 5,469 matched controls, which is consistent with the ones reported in previous studies. Alcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001).
This observational study ascertained the elevated incidence rates and risk of acute pancreatitis in Japanese patients with diabetes. The risk estimates in Japanese patients with diabetes were in agreement with the ones reported in previous studies, and the elevated risk of acute pancreatitis in patients with diabetes would be generalized in different locations/populations.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0053224</identifier><identifier>PMID: 23300896</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Age Factors ; Aged ; Alcoholism ; Biology ; Case-Control Studies ; Codes ; Comorbidity ; Databases, Factual ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes therapy ; Diabetics ; Drug abuse ; Dyslipidemia ; Epidemiology ; Female ; Gallstones ; Gastroenterology ; Health risks ; Hepatitis ; Hospitals ; Humans ; Incidence ; Information systems ; Japan - epidemiology ; Laboratories ; Male ; Medical research ; Medicine ; Metabolic disorders ; Middle Aged ; Obesity ; Observational studies ; Pancreatitis ; Pancreatitis - epidemiology ; Patient safety ; Patients ; Population ; Retrospective Studies ; Risk ; Risk analysis ; Risk factors ; Risk reduction ; Sex Factors ; Type 2 diabetes</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e53224-e53224</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Urushihara et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Urushihara et al 2012 Urushihara et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c736t-99551297f2e9640135d4789455614287a3f881c5215c7cf7a01ca12d39b0eb693</citedby><cites>FETCH-LOGICAL-c736t-99551297f2e9640135d4789455614287a3f881c5215c7cf7a01ca12d39b0eb693</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531339/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531339/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2101,2927,23865,27923,27924,53790,53792,79471,79472</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23300896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Folli, Franco</contributor><creatorcontrib>Urushihara, Hisashi</creatorcontrib><creatorcontrib>Taketsuna, Masanori</creatorcontrib><creatorcontrib>Liu, Ying</creatorcontrib><creatorcontrib>Oda, Eisei</creatorcontrib><creatorcontrib>Nakamura, Masaki</creatorcontrib><creatorcontrib>Nishiuma, Shinichi</creatorcontrib><creatorcontrib>Maeda, Rei</creatorcontrib><title>Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus.
We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; the odds ratios associated with diabetes mellitus and other comorbid risk factors were estimated with separate case-control analyses. In cohort analysis, the incidence of acute pancreatitis was higher in 14,707 diabetic patients than in 186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P<0.001) compared with non-diabetic patients in case-control analysis from 1,372 cases and 5,469 matched controls, which is consistent with the ones reported in previous studies. Alcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001).
This observational study ascertained the elevated incidence rates and risk of acute pancreatitis in Japanese patients with diabetes. The risk estimates in Japanese patients with diabetes were in agreement with the ones reported in previous studies, and the elevated risk of acute pancreatitis in patients with diabetes would be generalized in different locations/populations.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Alcoholism</subject><subject>Biology</subject><subject>Case-Control Studies</subject><subject>Codes</subject><subject>Comorbidity</subject><subject>Databases, Factual</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes therapy</subject><subject>Diabetics</subject><subject>Drug abuse</subject><subject>Dyslipidemia</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Gallstones</subject><subject>Gastroenterology</subject><subject>Health risks</subject><subject>Hepatitis</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Information systems</subject><subject>Japan - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Urushihara, Hisashi</au><au>Taketsuna, Masanori</au><au>Liu, Ying</au><au>Oda, Eisei</au><au>Nakamura, Masaki</au><au>Nishiuma, Shinichi</au><au>Maeda, Rei</au><au>Folli, Franco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-27</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e53224</spage><epage>e53224</epage><pages>e53224-e53224</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Increased risks of acute pancreatitis in patients with type 2 diabetes mellitus have been reported recently in several countries. We aimed to estimate the risks of acute pancreatitis in Japanese patients with diabetes mellitus.
We examined a large-scale hospital administrative database consisting of one million patients in 16 secondary medical care hospitals, from 2003 to 2010. The incidence rates of acute pancreatitis were estimated with cohort design; the odds ratios associated with diabetes mellitus and other comorbid risk factors were estimated with separate case-control analyses. In cohort analysis, the incidence of acute pancreatitis was higher in 14,707 diabetic patients than in 186,032 non-diabetic patients (4.75 vs. 1.65 per 1,000 patient-years) and increased in male patients and as age advanced. The adjusted odds ratio of acute pancreatitis in patients with diabetes mellitus was 1.86 (P<0.001) compared with non-diabetic patients in case-control analysis from 1,372 cases and 5,469 matched controls, which is consistent with the ones reported in previous studies. Alcoholism and gallstones were associated with a large increase in the risk of acute pancreatitis (adjusted odds ratio 13.40 and 14.29, respectively, P<0.001), although dyslipidemia was associated with significant risk reduction (adjusted odds ratio 0.62, P<0.001).
This observational study ascertained the elevated incidence rates and risk of acute pancreatitis in Japanese patients with diabetes. The risk estimates in Japanese patients with diabetes were in agreement with the ones reported in previous studies, and the elevated risk of acute pancreatitis in patients with diabetes would be generalized in different locations/populations.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23300896</pmid><doi>10.1371/journal.pone.0053224</doi><tpages>e53224</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Age Factors Aged Alcoholism Biology Case-Control Studies Codes Comorbidity Databases, Factual Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - epidemiology Diabetes therapy Diabetics Drug abuse Dyslipidemia Epidemiology Female Gallstones Gastroenterology Health risks Hepatitis Hospitals Humans Incidence Information systems Japan - epidemiology Laboratories Male Medical research Medicine Metabolic disorders Middle Aged Obesity Observational studies Pancreatitis Pancreatitis - epidemiology Patient safety Patients Population Retrospective Studies Risk Risk analysis Risk factors Risk reduction Sex Factors Type 2 diabetes |
| title | Increased risk of acute pancreatitis in patients with type 2 diabetes: an observational study using a Japanese hospital database |
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