CD271⁺ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells

Pancreatic stellate cells (PSCs) play a crucial role in the aggressive behavior of pancreatic cancer. Although heterogeneity of PSCs has been identified, the functional differences remain unclear. We characterized CD271⁺ PSCs in human pancreatic cancer. Immunohistochemistry for CD271 was performed f...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52682
Hauptverfasser:	Fujiwara, Kenji, Ohuchida, Kenoki, Mizumoto, Kazuhiro, Shindo, Koji, Eguchi, Daiki, Kozono, Shingo, Ikenaga, Naoki, Ohtsuka, Takao, Takahata, Shunichi, Aishima, Shinichi, Tanaka, Masao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Biology Cancer Carcinogenesis Carcinogens Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - mortality Carcinoma, Pancreatic Ductal - pathology Cell Communication Cell Movement Coculture Techniques Cytometry Extracellular matrix Female Fibroblasts Flow cytometry Gastroenterology Gene Expression Gene Expression Regulation, Neoplastic Growth factors Humans Immunohistochemistry Male Medical prognosis Medicine Melanoma Mice Mice, SCID Middle Aged Neoplasm Transplantation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Oncology Pancreatic cancer Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Stellate Cells - metabolism Polymerase chain reaction Prognosis Proportional Hazards Models Receptors, Nerve Growth Factor - genetics Receptors, Nerve Growth Factor - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Stellate cells Stromal cells Stromal Cells - metabolism Surgery Tissues Tumor Cells, Cultured Tumor Microenvironment Tumors Xenografts
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