HSP70 enhances immunosuppressive function of CD4(+)CD25(+)FoxP3(+) T regulatory cells and cytotoxicity in CD4(+)CD25(-) T cells

Human CD4(+)CD25(+)FoxP3(+) T regulatory cells (Tregs) control effector T cells and play a central role in peripheral tolerance and immune homeostasis. Heat shock protein 70 (HSP70) is a major immunomodulatory molecule, but its effect on the functions of Tregs is not well understood. To investigate...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e51747
Hauptverfasser:	Wachstein, Julian, Tischer, Sabine, Figueiredo, Constanca, Limbourg, Anne, Falk, Christine, Immenschuh, Stephan, Blasczyk, Rainer, Eiz-Vesper, Britta
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Adult AKT protein Antigens Apoptosis - immunology Autoimmune diseases Biology CD25 antigen CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism Cell adhesion & migration Cell proliferation Cloning Combined treatment Cytokines Cytotoxicity Effector cells Enzyme-Linked Immunosorbent Assay Exposure Female Flow Cytometry Fluorescent Antibody Technique Forkhead Transcription Factors - metabolism Foxp3 protein Granzymes - secretion Heat shock proteins Homeostasis HSP70 Heat-Shock Proteins - metabolism Hsp70 protein Humans Immune response Immune system Immunological tolerance Immunology Immunomodulation Immunoregulation Immunosuppression Immunosuppressive agents Immunosuppressive Agents - pharmacology Inflammation Interferon Interleukin 10 Interleukin 2 Interleukin-10 - metabolism Interleukin-2 Receptor alpha Subunit - metabolism JNK protein Lymphocytes Lymphocytes T Male MAP Kinase Kinase 4 - metabolism Medical schools Medicine Middle Aged p38 Mitogen-Activated Protein Kinases - metabolism Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Signal transduction T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Toxicity Transforming Growth Factor beta - metabolism Tumor necrosis factor-α γ-Interferon
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