A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade
As one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstr...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e52373-e52373 |
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| creator | Meng, Zhefeng Xin, Ruolei Zhong, Ping Zhang, Chiyu Abubakar, Yassir F Li, Jingyun Liu, Wei Zhang, Xiaoyan Xu, Jianqing |
| description | As one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstructing transmission map. Meanwhile, ample historic epidemic evidences were also reviewed to assist sequences analysis.
In the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999-2001. These analyzed results are in accordance with early epidemic investigations.
Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China. |
| doi_str_mv | 10.1371/journal.pone.0052373 |
| format | Article |
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In the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999-2001. These analyzed results are in accordance with early epidemic investigations.
Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0052373</identifier><identifier>PMID: 23300654</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acquired immune deficiency syndrome ; AIDS ; Analysis ; Bayes Theorem ; Bayesian analysis ; Biology ; China - epidemiology ; Disease prevention ; Epidemics ; Epidemics - statistics & numerical data ; HIV ; HIV Infections - epidemiology ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - physiology ; Human immunodeficiency virus ; Human Migration - statistics & numerical data ; Humans ; Laboratories ; Medicine ; Migration ; Reviews ; Sequence Analysis ; Time Factors</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e52373-e52373</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Meng et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Meng et al 2012 Meng et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d8a0f45edd4ca2c583750d175cd4f392dfd1ba5095b6b664cac2b15265835f763</citedby><cites>FETCH-LOGICAL-c692t-d8a0f45edd4ca2c583750d175cd4f392dfd1ba5095b6b664cac2b15265835f763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530601/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530601/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,2103,2929,23871,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23300654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yu, Xiao-Fang</contributor><creatorcontrib>Meng, Zhefeng</creatorcontrib><creatorcontrib>Xin, Ruolei</creatorcontrib><creatorcontrib>Zhong, Ping</creatorcontrib><creatorcontrib>Zhang, Chiyu</creatorcontrib><creatorcontrib>Abubakar, Yassir F</creatorcontrib><creatorcontrib>Li, Jingyun</creatorcontrib><creatorcontrib>Liu, Wei</creatorcontrib><creatorcontrib>Zhang, Xiaoyan</creatorcontrib><creatorcontrib>Xu, Jianqing</creatorcontrib><title>A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>As one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstructing transmission map. Meanwhile, ample historic epidemic evidences were also reviewed to assist sequences analysis.
In the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999-2001. These analyzed results are in accordance with early epidemic investigations.
Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China.</description><subject>Acquired immune deficiency syndrome</subject><subject>AIDS</subject><subject>Analysis</subject><subject>Bayes Theorem</subject><subject>Bayesian analysis</subject><subject>Biology</subject><subject>China - epidemiology</subject><subject>Disease prevention</subject><subject>Epidemics</subject><subject>Epidemics - statistics & numerical data</subject><subject>HIV</subject><subject>HIV Infections - epidemiology</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - physiology</subject><subject>Human immunodeficiency virus</subject><subject>Human Migration - statistics & numerical data</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Medicine</subject><subject>Migration</subject><subject>Reviews</subject><subject>Sequence Analysis</subject><subject>Time Factors</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNk11v0zAUhiMEYmPwDxBYQkJw0eKP2G64QCoVY5UmTRqwW-vUdlpPSdzZSWH_HmfNpgbtgitbx895z4fPybLXBE8Jk-TTte9CA9V06xs7xZhTJtmT7JgUjE4Exezpwf0oexHjdYLYTIjn2RFlDGPB8-PMzlFjf6ParQO0zjeohi3yJTpbXk0IWlyeYqm-LpBr0GLjGviMIMW8jS72ULQ3nW20jagMvkaEom3wO3dn8TsbECBjNRj7MntWQhXtq-E8yX6dfvu5OJucX3xfLubnEy0K2k7MDHCZc2tMroFqPmOSY0Mk1yYvWUFNacgKOC74SqyESJCmK8KpSCQvpWAn2du97rbyUQ0dioowKimRs4IkYrknjIdrtQ2uhnCrPDh1Z_BhrSC0TldW6Rw4l5gVlkNeSFEIQ1JqwlBJQOpZ0voyROtWtTXaNm2AaiQ6fmncRq39TjHOsMB9Mh8GgeBTJ2Orahe1rSporO9S3lQylucphYS--wd9vLqBWkMqwDWlT3F1L6rmuZQ4JznvqekjFPQfVTudxql0yT5y-DhySExr_7Rr6GJUyx-X_89eXI3Z9wfsxkLVbqKvun4Q4xjM96AOPsZgy4cmE6z6bbjvhuq3QQ3bkNzeHH7Qg9P9-LO_-iMBHg</recordid><startdate>20121226</startdate><enddate>20121226</enddate><creator>Meng, Zhefeng</creator><creator>Xin, Ruolei</creator><creator>Zhong, Ping</creator><creator>Zhang, Chiyu</creator><creator>Abubakar, Yassir F</creator><creator>Li, Jingyun</creator><creator>Liu, Wei</creator><creator>Zhang, Xiaoyan</creator><creator>Xu, Jianqing</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121226</creationdate><title>A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade</title><author>Meng, Zhefeng ; Xin, Ruolei ; Zhong, Ping ; Zhang, Chiyu ; Abubakar, Yassir F ; Li, Jingyun ; Liu, Wei ; Zhang, Xiaoyan ; Xu, Jianqing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d8a0f45edd4ca2c583750d175cd4f392dfd1ba5095b6b664cac2b15265835f763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>AIDS</topic><topic>Analysis</topic><topic>Bayes Theorem</topic><topic>Bayesian analysis</topic><topic>Biology</topic><topic>China - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meng, Zhefeng</au><au>Xin, Ruolei</au><au>Zhong, Ping</au><au>Zhang, Chiyu</au><au>Abubakar, Yassir F</au><au>Li, Jingyun</au><au>Liu, Wei</au><au>Zhang, Xiaoyan</au><au>Xu, Jianqing</au><au>Yu, Xiao-Fang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-26</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e52373</spage><epage>e52373</epage><pages>e52373-e52373</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>As one of prevalence HIV-1 strains in IDUs in Asia, the origination and full transmission map of CRF07_BC is of great interested and remains unclear. In the study, we collected 769 CRF07_BC derived sequences (including 45 sequences generated in our laboratory) from 12 provinces in China for reconstructing transmission map. Meanwhile, ample historic epidemic evidences were also reviewed to assist sequences analysis.
In the study, we collected 769 CRF07_BC derived sequences and identified 138 independent sequences from 12 provinces in China for subsequent phylogeographic tree analysis, Bayes Factor test and the estimation of state tMRCA. The analyses demonstrated that CRF07_BC was originated in 1993 in IDU in Yunnan province and then initially spread to Guangxi (eastern neighbor to Yunnan) in 1994, to Xinjiang (northwest) in 1995 and to Sichuan (northern neighbor to Yunnan) in 1996. The subsequent transmissions occurred from Yunnan to Liaoning (northeast) in 1997 and to Jiangsu in 1998. Interestingly, after the early introduction of CRF07_BC into Guangxi, Xinjiang and Sichuan, these three regions served as secondary epicenters for further spreading into Gansu, Ningxia, Qinghai, Beijing and Hunan during 1999-2001. These analyzed results are in accordance with early epidemic investigations.
Our data not just reconstructed the migration map of CRF07_BC, but also firstly revealed the active roles of these secondary epicenters in the dynamic migration of CRF07_BC in China.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23300654</pmid><doi>10.1371/journal.pone.0052373</doi><tpages>e52373</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Acquired immune deficiency syndrome AIDS Analysis Bayes Theorem Bayesian analysis Biology China - epidemiology Disease prevention Epidemics Epidemics - statistics & numerical data HIV HIV Infections - epidemiology HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - physiology Human immunodeficiency virus Human Migration - statistics & numerical data Humans Laboratories Medicine Migration Reviews Sequence Analysis Time Factors |
| title | A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade |
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