Functional differences between mitochondrial haplogroup T and haplogroup H in HEK293 cybrid cells

Epidemiological case-control studies have revealed associations between mitochondrial haplogroups and the onset and/or progression of various multifactorial diseases. For instance, mitochondrial haplogroup T was previously shown to be associated with vascular diseases, including coronary artery dise...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52367-e52367
Hauptverfasser:	Mueller, Edith E, Brunner, Susanne M, Mayr, Johannes A, Stanger, Olaf, Sperl, Wolfgang, Kofler, Barbara
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Amino acids Analysis Biochemistry Biology Cardiovascular disease Cell Proliferation Copy number Coronary artery Coronary artery disease Coronary heart disease Cybrids Cytotoxicity Deoxyribonucleic acid Development and progression Diabetes mellitus Diabetic retinopathy DNA DNA, Mitochondrial - genetics Enzymes Epidemiology Gene Dosage - genetics Growth rate Haplotypes Heart diseases HEK293 Cells - cytology HEK293 Cells - metabolism Humans Hydrogen Hydrogen peroxide Medical research Metabolism Mitochondria Mitochondria - enzymology Mitochondria - genetics Mitochondria - metabolism Mitochondrial DNA Motility Mutation Oxidative Phosphorylation Oxidative stress Oxidative Stress - genetics Oxygen Pediatrics Phosphorylation Phylogenetics Platelets Reactive oxygen species Retinopathy Studies Thrombocytes Type 2 diabetes Vascular diseases
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