IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?

Fibrosis is a serious consequence of Crohn's disease (CD), often necessitating surgical resection. We examined the hypothesis that IL-13 may promote collagen accumulation within the CD muscle microenvironment. Factors potentially modulating collagen deposition were examined in intestinal tissue...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52332-e52332
Hauptverfasser:	Bailey, Jennifer R, Bland, Paul W, Tarlton, John F, Peters, Iain, Moorghen, Moganaden, Sylvester, Paul A, Probert, Christopher S J, Whiting, Christine V
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Adolescent Adult Age Aged B cells Biology Cancer CD3 antigen CD45 antigen CD56 antigen Colitis Collagen Collagen - biosynthesis Collagen - metabolism Comparative analysis Crohn Disease - immunology Crohn Disease - metabolism Crohn Disease - pathology Crohn's disease Cytokines Deposition Down-Regulation Ethics Explants Extracellular matrix Female Fibroblasts Fibroblasts - metabolism Fibroblasts - pathology Fibrosis Gastroenterology Gelatinase A Gelatinase B Gene expression Humans Immunologi inom det medicinska området Immunology in the Medical Area Inflammation Inflammatory Bowel Disease Innate Lymphoid Cell Interleukin 13 Interleukin-13 - metabolism Interleukin-13 Receptor alpha1 Subunit - metabolism Interstitial collagenase Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Intestine Lymphocytes - cytology Lymphocytes - immunology Lymphoid cells Male Matrix metalloproteinase Matrix Metalloproteinases - biosynthesis Medicine Middle Aged Muscles Muscles - metabolism Muscles - pathology Nitrogen Rodents Smooth muscle Stat6 protein Surgery Synthesis Tumor necrosis factor-TNF Tumor necrosis factor-α Ulcerative colitis Womens health Young Adult
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