Establishment of a TGFβ-induced post-transcriptional EMT gene signature
A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite...
Gespeichert in:
| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e52624 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | e52624 |
| container_title | PloS one |
| container_volume | 7 |
| creator | Hussey, George S Link, Laura A Brown, Andrew S Howley, Breege V Chaudhury, Arindam Howe, Philip H |
| description | A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, the identity and validation of cancer specific 'signature genes' remains elusive, partially because the transcriptome does not mirror the proteome. The simplification associated with transcriptomic profiling does not take into consideration changes in the relative expression among transcripts that arise due to post-transcriptional regulatory events. We have previously shown that TGFβ post-transcriptionally regulates epithelial-mesenchymal transition (EMT) by causing increased expression of two transcripts, Dab2 and ILEI, by modulating hnRNP E1 phosphorylation. Using a genome-wide combinatorial approach involving expression profiling and RIP-Chip analysis, we have identified a cohort of translationally regulated mRNAs that are induced during TGFβ-mediated EMT. Coordinated translational regulation by hnRNP E1 constitutes a post-transcriptional regulon inhibiting the expression of related EMT-facilitating genes, thus enabling the cell to rapidly and coordinately regulate multiple EMT-facilitating genes. |
| doi_str_mv | 10.1371/journal.pone.0052624 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1327199360</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_3050880efe6e48b98a4b4cc87630efa2</doaj_id><sourcerecordid>2945505401</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-91d12ad5ac7cd311743f6c8e6950069a7af895daa8f9d193430760583b2289393</originalsourceid><addsrcrecordid>eNp1Uctu1DAUtRCIloE_QBCJdQY_YsfeIKFq-pCK2Axr68Z2ph5l4mA7lfgtPoRvqttJq3bBytb1efkehD4SvCasJV_3YY4jDOspjG6NMaeCNq_QKVGM1oJi9vrZ_QS9S2lfQEwK8RadUEYlJ6Q9RZeblKEbfLo5uDFXoa-g2l6c__tb-9HOxtlqCinXOcKYTPRT9qGYVpsf22rnRlclvxshz9G9R296GJL7sJwr9Ot8sz27rK9_Xlydfb-uTUmYa0UsoWA5mNZYViI0rBdGOqE4xkJBC71U3ALIXtmSv2G4FZhL1lEqFVNshT4fdachJL0sIWnCaEuUYgIXxNURYQPs9RT9AeIfHcDrh0GIOw0xezM4zTDHUmLXO-Ea2SkJTdcYI1vByhBo0fq2uM3dwVlTdhRheCH68mX0N3oXbjXjtOXlcyv0ZRGI4ffsUv5P5OaIMjGkFF3_5ECwvm_7kaXv29ZL24X26Xm6J9JjvewO1maoPA</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1327199360</pqid></control><display><type>article</type><title>Establishment of a TGFβ-induced post-transcriptional EMT gene signature</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Public Library of Science (PLoS)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Hussey, George S ; Link, Laura A ; Brown, Andrew S ; Howley, Breege V ; Chaudhury, Arindam ; Howe, Philip H</creator><contributor>Katz, Elad</contributor><creatorcontrib>Hussey, George S ; Link, Laura A ; Brown, Andrew S ; Howley, Breege V ; Chaudhury, Arindam ; Howe, Philip H ; Katz, Elad</creatorcontrib><description>A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, the identity and validation of cancer specific 'signature genes' remains elusive, partially because the transcriptome does not mirror the proteome. The simplification associated with transcriptomic profiling does not take into consideration changes in the relative expression among transcripts that arise due to post-transcriptional regulatory events. We have previously shown that TGFβ post-transcriptionally regulates epithelial-mesenchymal transition (EMT) by causing increased expression of two transcripts, Dab2 and ILEI, by modulating hnRNP E1 phosphorylation. Using a genome-wide combinatorial approach involving expression profiling and RIP-Chip analysis, we have identified a cohort of translationally regulated mRNAs that are induced during TGFβ-mediated EMT. Coordinated translational regulation by hnRNP E1 constitutes a post-transcriptional regulon inhibiting the expression of related EMT-facilitating genes, thus enabling the cell to rapidly and coordinately regulate multiple EMT-facilitating genes.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0052624</identifier><identifier>PMID: 23285117</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Animals ; Base Sequence ; Biochemistry ; Biology ; Cancer ; Cluster Analysis ; Combinatorial analysis ; EMT gene ; Epithelial-Mesenchymal Transition - genetics ; Gene expression ; Gene Expression Profiling ; Gene Expression Regulation - drug effects ; Genes ; Genomes ; Genomics ; Heterogeneous-Nuclear Ribonucleoproteins - metabolism ; Identification ; Kinases ; Medicine ; Mesenchyme ; Metastasis ; Mice ; Molecular biology ; Nucleic Acid Conformation ; Phosphorylation ; Post-transcription ; Protein Binding ; Protein Biosynthesis ; Proteomes ; Proteomics ; Reproducibility of Results ; Response Elements ; RNA Processing, Post-Transcriptional - drug effects ; RNA, Messenger - chemistry ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Transforming Growth Factor beta - pharmacology ; Yeast</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e52624</ispartof><rights>2012 Hussey et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Hussey et al 2012 Hussey et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-91d12ad5ac7cd311743f6c8e6950069a7af895daa8f9d193430760583b2289393</citedby><cites>FETCH-LOGICAL-c526t-91d12ad5ac7cd311743f6c8e6950069a7af895daa8f9d193430760583b2289393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527574/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527574/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,2102,2928,23866,27924,27925,53791,53793,79600,79601</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23285117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Katz, Elad</contributor><creatorcontrib>Hussey, George S</creatorcontrib><creatorcontrib>Link, Laura A</creatorcontrib><creatorcontrib>Brown, Andrew S</creatorcontrib><creatorcontrib>Howley, Breege V</creatorcontrib><creatorcontrib>Chaudhury, Arindam</creatorcontrib><creatorcontrib>Howe, Philip H</creatorcontrib><title>Establishment of a TGFβ-induced post-transcriptional EMT gene signature</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, the identity and validation of cancer specific 'signature genes' remains elusive, partially because the transcriptome does not mirror the proteome. The simplification associated with transcriptomic profiling does not take into consideration changes in the relative expression among transcripts that arise due to post-transcriptional regulatory events. We have previously shown that TGFβ post-transcriptionally regulates epithelial-mesenchymal transition (EMT) by causing increased expression of two transcripts, Dab2 and ILEI, by modulating hnRNP E1 phosphorylation. Using a genome-wide combinatorial approach involving expression profiling and RIP-Chip analysis, we have identified a cohort of translationally regulated mRNAs that are induced during TGFβ-mediated EMT. Coordinated translational regulation by hnRNP E1 constitutes a post-transcriptional regulon inhibiting the expression of related EMT-facilitating genes, thus enabling the cell to rapidly and coordinately regulate multiple EMT-facilitating genes.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Cancer</subject><subject>Cluster Analysis</subject><subject>Combinatorial analysis</subject><subject>EMT gene</subject><subject>Epithelial-Mesenchymal Transition - genetics</subject><subject>Gene expression</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Heterogeneous-Nuclear Ribonucleoproteins - metabolism</subject><subject>Identification</subject><subject>Kinases</subject><subject>Medicine</subject><subject>Mesenchyme</subject><subject>Metastasis</subject><subject>Mice</subject><subject>Molecular biology</subject><subject>Nucleic Acid Conformation</subject><subject>Phosphorylation</subject><subject>Post-transcription</subject><subject>Protein Binding</subject><subject>Protein Biosynthesis</subject><subject>Proteomes</subject><subject>Proteomics</subject><subject>Reproducibility of Results</subject><subject>Response Elements</subject><subject>RNA Processing, Post-Transcriptional - drug effects</subject><subject>RNA, Messenger - chemistry</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Transforming Growth Factor beta - pharmacology</subject><subject>Yeast</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNp1Uctu1DAUtRCIloE_QBCJdQY_YsfeIKFq-pCK2Axr68Z2ph5l4mA7lfgtPoRvqttJq3bBytb1efkehD4SvCasJV_3YY4jDOspjG6NMaeCNq_QKVGM1oJi9vrZ_QS9S2lfQEwK8RadUEYlJ6Q9RZeblKEbfLo5uDFXoa-g2l6c__tb-9HOxtlqCinXOcKYTPRT9qGYVpsf22rnRlclvxshz9G9R296GJL7sJwr9Ot8sz27rK9_Xlydfb-uTUmYa0UsoWA5mNZYViI0rBdGOqE4xkJBC71U3ALIXtmSv2G4FZhL1lEqFVNshT4fdachJL0sIWnCaEuUYgIXxNURYQPs9RT9AeIfHcDrh0GIOw0xezM4zTDHUmLXO-Ea2SkJTdcYI1vByhBo0fq2uM3dwVlTdhRheCH68mX0N3oXbjXjtOXlcyv0ZRGI4ffsUv5P5OaIMjGkFF3_5ECwvm_7kaXv29ZL24X26Xm6J9JjvewO1maoPA</recordid><startdate>20121220</startdate><enddate>20121220</enddate><creator>Hussey, George S</creator><creator>Link, Laura A</creator><creator>Brown, Andrew S</creator><creator>Howley, Breege V</creator><creator>Chaudhury, Arindam</creator><creator>Howe, Philip H</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121220</creationdate><title>Establishment of a TGFβ-induced post-transcriptional EMT gene signature</title><author>Hussey, George S ; Link, Laura A ; Brown, Andrew S ; Howley, Breege V ; Chaudhury, Arindam ; Howe, Philip H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-91d12ad5ac7cd311743f6c8e6950069a7af895daa8f9d193430760583b2289393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Cancer</topic><topic>Cluster Analysis</topic><topic>Combinatorial analysis</topic><topic>EMT gene</topic><topic>Epithelial-Mesenchymal Transition - genetics</topic><topic>Gene expression</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Genes</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Heterogeneous-Nuclear Ribonucleoproteins - metabolism</topic><topic>Identification</topic><topic>Kinases</topic><topic>Medicine</topic><topic>Mesenchyme</topic><topic>Metastasis</topic><topic>Mice</topic><topic>Molecular biology</topic><topic>Nucleic Acid Conformation</topic><topic>Phosphorylation</topic><topic>Post-transcription</topic><topic>Protein Binding</topic><topic>Protein Biosynthesis</topic><topic>Proteomes</topic><topic>Proteomics</topic><topic>Reproducibility of Results</topic><topic>Response Elements</topic><topic>RNA Processing, Post-Transcriptional - drug effects</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Transforming Growth Factor beta - pharmacology</topic><topic>Yeast</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hussey, George S</creatorcontrib><creatorcontrib>Link, Laura A</creatorcontrib><creatorcontrib>Brown, Andrew S</creatorcontrib><creatorcontrib>Howley, Breege V</creatorcontrib><creatorcontrib>Chaudhury, Arindam</creatorcontrib><creatorcontrib>Howe, Philip H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hussey, George S</au><au>Link, Laura A</au><au>Brown, Andrew S</au><au>Howley, Breege V</au><au>Chaudhury, Arindam</au><au>Howe, Philip H</au><au>Katz, Elad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Establishment of a TGFβ-induced post-transcriptional EMT gene signature</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-20</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e52624</spage><pages>e52624-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>A major challenge in the clinical management of human cancers is to accurately stratify patients according to risk and likelihood of a favorable response. Stratification is confounded by significant phenotypic heterogeneity in some tumor types, often without obvious criteria for subdivision. Despite intensive transcriptional array analyses, the identity and validation of cancer specific 'signature genes' remains elusive, partially because the transcriptome does not mirror the proteome. The simplification associated with transcriptomic profiling does not take into consideration changes in the relative expression among transcripts that arise due to post-transcriptional regulatory events. We have previously shown that TGFβ post-transcriptionally regulates epithelial-mesenchymal transition (EMT) by causing increased expression of two transcripts, Dab2 and ILEI, by modulating hnRNP E1 phosphorylation. Using a genome-wide combinatorial approach involving expression profiling and RIP-Chip analysis, we have identified a cohort of translationally regulated mRNAs that are induced during TGFβ-mediated EMT. Coordinated translational regulation by hnRNP E1 constitutes a post-transcriptional regulon inhibiting the expression of related EMT-facilitating genes, thus enabling the cell to rapidly and coordinately regulate multiple EMT-facilitating genes.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23285117</pmid><doi>10.1371/journal.pone.0052624</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-12, Vol.7 (12), p.e52624 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1327199360 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Animals Base Sequence Biochemistry Biology Cancer Cluster Analysis Combinatorial analysis EMT gene Epithelial-Mesenchymal Transition - genetics Gene expression Gene Expression Profiling Gene Expression Regulation - drug effects Genes Genomes Genomics Heterogeneous-Nuclear Ribonucleoproteins - metabolism Identification Kinases Medicine Mesenchyme Metastasis Mice Molecular biology Nucleic Acid Conformation Phosphorylation Post-transcription Protein Binding Protein Biosynthesis Proteomes Proteomics Reproducibility of Results Response Elements RNA Processing, Post-Transcriptional - drug effects RNA, Messenger - chemistry RNA, Messenger - genetics RNA, Messenger - metabolism Transforming Growth Factor beta - pharmacology Yeast |
| title | Establishment of a TGFβ-induced post-transcriptional EMT gene signature |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T05%3A35%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Establishment%20of%20a%20TGF%CE%B2-induced%20post-transcriptional%20EMT%20gene%20signature&rft.jtitle=PloS%20one&rft.au=Hussey,%20George%20S&rft.date=2012-12-20&rft.volume=7&rft.issue=12&rft.spage=e52624&rft.pages=e52624-&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0052624&rft_dat=%3Cproquest_plos_%3E2945505401%3C/proquest_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1327199360&rft_id=info:pmid/23285117&rft_doaj_id=oai_doaj_org_article_3050880efe6e48b98a4b4cc87630efa2&rfr_iscdi=true |