Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence

Deletion of the first exon of calmodulin-lysine N-methyltransferase (CaM KMT, previously C2orf34) has been reported in two multigene deletion syndromes, but additional studies on the gene have not been reported. Here we show that in the cells from 2p21 deletion patients the loss of CaM KMT expressio...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52425
Hauptverfasser:	Magen, Sophia, Magnani, Roberta, Haziza, Sitvanit, Hershkovitz, Eli, Houtz, Robert, Cambi, Franca, Parvari, Ruti
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Benzoquinones - pharmacology Biology Calcium-binding protein Calmodulin Calmodulin - metabolism Calmodulin-lysine N-methyltransferase Cancer Cell Line Cells (Biology) Chromosome Deletion Chromosomes, Human, Pair 21 - enzymology Chromosomes, Human, Pair 21 - genetics Clonal deletion Comparative analysis Craniofacial Abnormalities - enzymology Craniofacial Abnormalities - genetics Cystinuria - enzymology Cystinuria - genetics Cytoplasm Disorders DNA methylation Exons Geldanamycin Gene deletion Gene expression Golgi apparatus Green Fluorescent Proteins - metabolism Health sciences Heat shock proteins Horticulture HSP90 Heat-Shock Proteins - chemistry HSP90 Heat-Shock Proteins - metabolism Hsp90 protein Humans Intellectual Disability - enzymology Intellectual Disability - genetics Kinases Lactams, Macrocyclic - pharmacology Localization Lysine Medicine Methylation Methylation - drug effects Methyltransferase Methyltransferases - chemistry Methyltransferases - genetics Methyltransferases - metabolism Mice Mice, Inbred ICR Mitochondrial Diseases - enzymology Mitochondrial Diseases - genetics Molecular Sequence Data Muscle Hypotonia - enzymology Muscle Hypotonia - genetics N-Methyltransferase Nuclei Nuclei (cytology) Patients Penicillin Protein Binding - drug effects Protein Stability - drug effects Protein Structure, Tertiary Protein Transport - drug effects Proteins Proteolysis - drug effects Recombinant Fusion Proteins - metabolism Subcellular Fractions - drug effects Subcellular Fractions - enzymology Target recognition Tissues Transcription Transcription, Genetic - drug effects Transferases Virology
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