Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients
To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion. A technique desc...
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| Veröffentlicht in: | PloS one 2012-12, Vol.7 (12), p.e52656-e52656 |
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| creator | Leigh, Richard Jen, Shyian S Varma, Daniel D Hillis, Argye E Barker, Peter B |
| description | To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion.
A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.
ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.
The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption. |
| doi_str_mv | 10.1371/journal.pone.0052656 |
| format | Article |
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A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.
ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.
The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0052656</identifier><identifier>PMID: 23285132</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Aged ; Biology ; Blood ; Blood-brain barrier ; Blood-Brain Barrier - metabolism ; Blood-Brain Barrier - pathology ; Brain - pathology ; Brain cancer ; Brain research ; Brain tumors ; Comparative analysis ; Damage detection ; Engineering ; Female ; Humans ; Inspection ; Ischemia ; Magnetic Resonance Imaging ; Male ; Medicine ; Middle Aged ; Neuroimaging ; Neurology ; NMR ; Nuclear magnetic resonance ; Patients ; Perfusion ; Permeability ; ROC Curve ; Stroke ; Stroke - diagnosis ; Stroke patients ; Time Factors</subject><ispartof>PloS one, 2012-12, Vol.7 (12), p.e52656-e52656</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Leigh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Leigh et al 2012 Leigh et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-125f01f08783511a328669dc0be39b27acacaaf83c4f60e8693cade308e37f013</citedby><cites>FETCH-LOGICAL-c692t-125f01f08783511a328669dc0be39b27acacaaf83c4f60e8693cade308e37f013</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527589/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527589/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2095,2914,23846,27903,27904,53769,53771,79346,79347</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23285132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Herholz, Karl</contributor><creatorcontrib>Leigh, Richard</creatorcontrib><creatorcontrib>Jen, Shyian S</creatorcontrib><creatorcontrib>Varma, Daniel D</creatorcontrib><creatorcontrib>Hillis, Argye E</creatorcontrib><creatorcontrib>Barker, Peter B</creatorcontrib><title>Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion.
A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.
ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.
The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption.</description><subject>Adult</subject><subject>Aged</subject><subject>Biology</subject><subject>Blood</subject><subject>Blood-brain barrier</subject><subject>Blood-Brain Barrier - metabolism</subject><subject>Blood-Brain Barrier - pathology</subject><subject>Brain - pathology</subject><subject>Brain cancer</subject><subject>Brain research</subject><subject>Brain tumors</subject><subject>Comparative analysis</subject><subject>Damage detection</subject><subject>Engineering</subject><subject>Female</subject><subject>Humans</subject><subject>Inspection</subject><subject>Ischemia</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medicine</subject><subject>Middle Aged</subject><subject>Neuroimaging</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Patients</subject><subject>Perfusion</subject><subject>Permeability</subject><subject>ROC Curve</subject><subject>Stroke</subject><subject>Stroke - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leigh, Richard</au><au>Jen, Shyian S</au><au>Varma, Daniel D</au><au>Hillis, Argye E</au><au>Barker, Peter B</au><au>Herholz, Karl</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-12-20</date><risdate>2012</risdate><volume>7</volume><issue>12</issue><spage>e52656</spage><epage>e52656</epage><pages>e52656-e52656</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>To determine if applying an arrival time correction (ATC) to dynamic susceptibility contrast (DSC) based permeability imaging will improve its ability to identify contrast leakage in stroke patients for whom the shape of the measured curve may be very different due to hypoperfusion.
A technique described in brain tumor patients was adapted to incorporate a correction for delayed contrast delivery due to perfusion deficits. This technique was applied to the MRIs of 9 stroke patients known to have blood-brain barrier (BBB) disruption on T1 post contrast imaging. Regions of BBB damage were compared with normal tissue from the contralateral hemisphere. Receiver operating characteristic (ROC) analysis was performed to compare the detection of BBB damage before and after ATC.
ATC improved the area under the curve (AUC) of the ROC from 0.53 to 0.70. The sensitivity improved from 0.51 to 0.67 and the specificity improved from 0.57 to 0.66. Visual inspection of the ROC curve revealed that the performance of the uncorrected analysis was worse than random guess at some thresholds.
The ability of DSC permeability imaging to identify contrast enhancing tissue in stroke patients improved considerably when an ATC was applied. Using DSC permeability imaging in stroke patients without an ATC may lead to false identification of BBB disruption.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23285132</pmid><doi>10.1371/journal.pone.0052656</doi><tpages>e52656</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Biology Blood Blood-brain barrier Blood-Brain Barrier - metabolism Blood-Brain Barrier - pathology Brain - pathology Brain cancer Brain research Brain tumors Comparative analysis Damage detection Engineering Female Humans Inspection Ischemia Magnetic Resonance Imaging Male Medicine Middle Aged Neuroimaging Neurology NMR Nuclear magnetic resonance Patients Perfusion Permeability ROC Curve Stroke Stroke - diagnosis Stroke patients Time Factors |
| title | Arrival time correction for dynamic susceptibility contrast MR permeability imaging in stroke patients |
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