Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition

Physiologically relevant pre-clinical ex vivo models recapitulating CNS tumor micro-environmental complexity will aid development of biologically-targeted agents. We present comprehensive characterization of tumor aggregates generated using the 3D Rotary Cell Culture System (RCCS). CNS cancer cell l...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52335-e52335
Hauptverfasser:	Smith, Stuart J, Wilson, Martin, Ward, Jennifer H, Rahman, Cheryl V, Peet, Andrew C, Macarthur, Donald C, Rose, Felicity R A J, Grundy, Richard G, Rahman, Ruman
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggregates Antineoplastic Agents - pharmacology Biology Brain Brain cancer Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain research Brain tumors Cancer Cancer genetics Cancer therapies Cell culture Cell Line, Tumor Cell Proliferation Central nervous system Chemotherapy Childrens health Clinical trials Cluster Analysis Cytotoxicity Drug dosages Drug Resistance, Neoplasm Drug screening Drug testing Epigenetic inheritance Epigenetics Extracellular Matrix - metabolism Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Genomes Genomics Glioblastoma Glioblastoma cells Gliomas Heterogeneity Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Humans Immunohistochemistry Magnetic resonance Magnetic resonance spectroscopy Medical research Medical screening Medicine Metabolites Metabolome MicroRNA miRNA Nuclear magnetic resonance spectroscopy Ovarian cancer Oxygen Oxygen tension Pediatrics Pharmacy Phenotype Primary Cell Culture Quality R&D Research & development Ribonucleic acid RNA Sensitivity Sensitivity analysis Spectroscopy Spheroids, Cellular Stem cells Three dimensional models Tissue engineering Tumor cell lines Tumor cells Tumor Cells, Cultured Tumor Microenvironment Tumors
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