Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays

Cholesteatoma is a gradually expanding destructive epithelial lesion within the middle ear. It can cause extensive local tissue destruction in the temporal bone and can initially lead to the development of conductive hearing loss via ossicular erosion. As the disease progresses, sensorineural hearin...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52718-e52718
Hauptverfasser:	Klenke, Christin, Janowski, Sebastian, Borck, Daniela, Widera, Darius, Ebmeyer, Jörg, Kalinowski, Jörn, Leichtle, Anke, Hofestädt, Ralf, Upile, Tahwinder, Kaltschmidt, Christian, Kaltschmidt, Barbara, Sudhoff, Holger
Format:	Artikel
Sprache:	eng
Schlagworte:	Auditory defects Bioinformatics Biology Bone loss Cell interactions Cellular signal transduction Cholesteatoma Cholesteatoma, Middle Ear - genetics Cholesteatoma, Middle Ear - metabolism Cholesteatoma, Middle Ear - pathology Cluster Analysis Computational Biology - methods Connexins Disease transmission DNA microarrays Ear Ear canal Eardrum Gelatinase B Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genomes Genomics Health aspects Hearing loss Humans Infection Infections Inflammation Keratins - genetics Keratins - metabolism Matrix metalloproteinases Medicine Melanoma Meningitis Metabolism Metastases Middle ear Neurosciences Otolaryngology Paralysis Pathogenesis Protein folding Protein interaction Protein Interaction Mapping Protein Interaction Maps Protein metabolism Protein turnover Protein-protein interactions Proteins Reproducibility of Results RNA polymerase Signal Transduction Skin Skin cancer Surgery Temporal bone Transcriptome Transduction Tumors Vertigo
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