Elucidation of motifs in ribosomal protein S9 that mediate its nucleolar localization and binding to NPM1/nucleophosmin

Biogenesis of eukaryotic ribosomes occurs mainly in a specific subnuclear compartment, the nucleolus, and involves the coordinated assembly of ribosomal RNA and ribosomal proteins. Identification of amino acid sequences mediating nucleolar localization of ribosomal proteins may provide important clu...

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Veröffentlicht in:	PloS one 2012-12, Vol.7 (12), p.e52476
1. Verfasser:	Lindstrom, MS
Format:	Artikel
Sprache:	eng
Schlagworte:	Accumulation Amino Acid Motifs Amino Acid Sequence Amino acids Binding sites Biology Biosynthesis C-Terminus Cancer Cell cycle Cell Line, Tumor Cell Nucleolus - metabolism Cell Survival Clonal deletion Cytoplasm Deletion mutant Fibrillarin Fluorescence Gene sequencing Green fluorescent protein Green Fluorescent Proteins - metabolism Humans Localization Molecular Sequence Data Mutant Proteins - chemistry Mutant Proteins - metabolism Mutants N-Terminus Nuclear Localization Signals Nuclear Proteins - metabolism Nucleoli Phosphorylation Prokaryotes Protein Binding Protein Structure, Tertiary Protein Transport Proteins Recombinant Fusion Proteins - metabolism Retention Ribonucleic acid Ribosomal DNA Ribosomal protein S9 Ribosomal proteins Ribosomal Proteins - chemistry Ribosomal Proteins - metabolism Ribosomal RNA Ribosomes RNA rRNA Sequence Deletion Structure-Activity Relationship
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